Perspectives of aminoacylases in biocatalytic synthesis of N-acyl-amino acids surfactants.
N-acyl-amino acids
Aminoacylase
Biobased surfactants
Biocatalysis
Green chemistry
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
received:
04
07
2024
accepted:
07
10
2024
revised:
06
10
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Many industrial processes are performed using harmful chemicals. The current technical synthesis of N-acyl-amino acids relies on acyl chlorides, which are typically obtained from phosgene chemistry. A greener alternative is the application of whole cells or enzymes to carry out synthesis in an environmentally friendly manner. Aminoacylases belong to the hydrolase family and the resolution of racemic mixtures of N-acetyl-amino acids is a well-known industrial process. Several new enzymes accepting long-chain fatty acids as substrates were discovered in recent years. This article reviews the synthetic potential of aminoacylases to produce biobased N-acyl-amino acid surfactants. The focus lays on a survey of the different types of aminoacylases available for synthesis and their reaction products. The enzymes are categorized according to their protein family classification and their biochemical characteristics including substrate spectra, reaction optima and process stability, both in hydrolysis and under process conditions suitable for synthesis. Finally, the benefits and future challenges of enzymatic N-acyl-amino acid synthesis with aminoacylases will be discussed. KEY POINTS: • Enzymatic synthesis of N-acyl-amino acids, biobased surfactants by aminoacylases.
Identifiants
pubmed: 39453420
doi: 10.1007/s00253-024-13328-7
pii: 10.1007/s00253-024-13328-7
doi:
Substances chimiques
Surface-Active Agents
0
Amino Acids
0
Amidohydrolases
EC 3.5.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
495Informations de copyright
© 2024. The Author(s).
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