Thrombospondins in human aortic aneurysms.
THBS
TSP
aortic aneurysm
human samples
thrombospondins
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
08
02
2022
received:
03
09
2021
accepted:
12
02
2022
pubmed:
17
3
2022
medline:
21
9
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently. Aortic aneurysms are related to the impairment of vascular remodeling, in which extracellular matrix proteins seem to play an important role. Thus, research in thrombospondins, and their potential role in aneurysm development is progressively gaining importance. Nevertheless, studies showing thrombospondin dysregulation in human samples are still scarce. Although studies performed in vitro and in vivo models are essential to understand the molecular mechanisms and pathways underlying the disorder, descriptive studies in human samples are also necessary to ascertain their real value as biomarkers and/or novel therapeutic targets. The present article reviews the latest findings regarding the role of thrombospondins in aortic aneurysm development, paying particular attention to the studies performed in human samples.
Substances chimiques
Biomarkers
0
Extracellular Matrix Proteins
0
Thrombospondins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
982-994Subventions
Organisme : Generalitat Valenciana
ID : ACIF/2017/138
Organisme : Instituto de Salud Carlos III
ID : PI20/00075
Organisme : Instituto de Salud Carlos III
ID : PI20/01171
Organisme : Sociedad Española de Trombosis y Hemostasia
Informations de copyright
© 2022 International Union of Biochemistry and Molecular Biology.
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