Temporal changes in the brain lipidome during neurodevelopment of Smith-Lemli-Opitz syndrome mice.

Animals Brain / metabolism Cholesterol / metabolism Lipidomics Lipids Mice Oxidoreductases Acting on CH-CH Group Donors Smith-Lemli-Opitz Syndrome / genetics

Journal

The Analyst
ISSN: 1364-5528
Titre abrégé: Analyst
Pays: England
ID NLM: 0372652

Informations de publication

Date de publication:
11 Apr 2022
Historique:
pubmed: 17 3 2022
medline: 14 4 2022
entrez: 16 3 2022
Statut: epublish

Résumé

Neurodevelopment is an intricately orchestrated program of cellular events that occurs with tight temporal and spatial regulation. While it is known that the development and proper functioning of the brain, which is the second most lipid rich organ behind adipose tissue, greatly rely on lipid metabolism and signaling, the temporal lipidomic changes that occur throughout the course of neurodevelopment have not been investigated. Smith-Lemli-Opitz syndrome is a metabolic disorder caused by genetic mutations in the

Identifiants

DOI: 10.1039/d2an00137c PMID: 35293916 PMC: PMC9018458
pubmed: 35293916
doi: 10.1039/d2an00137c
pmc: PMC9018458
mid: NIHMS1790534
doi:

Substances chimiques

Lipids 0
Cholesterol 97C5T2UQ7J
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1611-1621

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD103524
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007750
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092659
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002318
Pays : United States

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Auteurs

Amy Li (A)

Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA. libinxu@uw.edu.

Kelly M Hines (KM)

Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA. libinxu@uw.edu.

Dylan H Ross (DH)

Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA. libinxu@uw.edu.

James W MacDonald (JW)

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

Libin Xu (L)

Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA. libinxu@uw.edu.
ORCID: 0000-0003-1021-5200

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Lipidomique › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Lipides › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Temporal changes in the brain lipidome during...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme des stéroïdes › Syndrome de Smith-Lemli-Optiz › Temporal changes in the brain lipidome during...