Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases.
Cerebrovascular disease
Cortical thickness
Empathy
Neurodegenerative disease
Social cognition
White matter hyperintensities
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
17
08
2021
accepted:
22
02
2022
pubmed:
17
3
2022
medline:
24
6
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
Change in empathy is an increasingly recognised symptom of neurodegenerative diseases and contributes to caregiver burden and patient distress. Empathy impairment has been associated with brain atrophy but its relationship to white matter hyperintensities (WMH) is unknown. We aimed to investigate the relationships amongst WMH, brain atrophy, and empathy deficits in neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with Alzheimer's disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), Parkinson's disease, or cerebrovascular disease (CVD) were included. Empathy was assessed using the Interpersonal Reactivity Index. WMH were measured using a semi-automatic segmentation and FreeSurfer was used to measure cortical thickness. A heterogeneous pattern of cortical thinning was found between groups, with FTD showing thinning in frontotemporal regions and CVD in left superior parietal, left insula, and left postcentral. Results from both univariate and multivariate analyses revealed that several variables were associated with empathy, particularly cortical thickness in the fronto-insulo-temporal and cingulate regions, sex (female), global cognition, and right parietal and occipital WMH. Our results suggest that cortical atrophy and WMH may be associated with empathy deficits in neurodegenerative and cerebrovascular diseases. Future work should consider investigating the longitudinal effects of WMH and atrophy on empathy deficits in neurodegenerative and cerebrovascular diseases.
Identifiants
pubmed: 35294697
doi: 10.1007/s11357-022-00539-x
pii: 10.1007/s11357-022-00539-x
pmc: PMC9213606
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1575-1598Investigateurs
Michael Strong
(M)
Peter Kleinstiver
(P)
Jane Lawrence-Dewar
(J)
Natalie Rashkovan
(N)
Susan Bronskil
(S)
Julia Fraser
(J)
Bill McIlroy
(B)
Ben Cornish
(B)
Karen Van Ooteghem
(K)
Frederico Faria
(F)
Yanina Sarquis-Adamson
(Y)
Alanna Black
(A)
Barry Greenberg
(B)
Wendy Hatch
(W)
Chris Hudson
(C)
Elena Leontieva
(E)
Ed Margolin
(E)
Efrem Mandelcorn
(E)
Faryan Tayyari
(F)
Sherif Defrawy
(S)
Don Brien
(D)
Ying Chen
(Y)
Brian Coe
(B)
Doug Munoz
(D)
Alisia Southwell
(A)
Dennis Bulman
(D)
Allison Ann Dilliott
(AA)
Mahdi Ghani
(M)
Rob Hegele
(R)
John Robinson
(J)
Ekaterina Rogaeva
(E)
Sali Farhan
(S)
Seyyed Mohammad Hassan Haddad
(SMH)
Nuwan Nanayakkara
(N)
Courtney Berezuk
(C)
Sabrina Adamo
(S)
Malcolm Binns
(M)
Wendy Lou
(W)
Athena Theyers
(A)
Abiramy Uthirakumaran
(A)
Guangyong Gy Zou
(GG)
Sujeevini Sujanthan
(S)
Mojdeh Zamyadi
(M)
David Munoz
(D)
Roger A Dixon
(RA)
John Woulfe
(J)
Brian Levine
(B)
J B Orange
(JB)
Alicia Peltsch
(A)
Angela Troyer
(A)
Marvin Chum
(M)
Informations de copyright
© 2022. The Author(s), under exclusive licence to American Aging Association.
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