Striatum expresses region-specific plasticity consistent with distinct memory abilities.
anti-Hebbian plasticity
computational modeling
learning and memory
memory flexibility
memory maintenance
motor skill learning
procedural learning
spike-timing-dependent plasticity
striatum
synaptic plasticity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
15 03 2022
15 03 2022
Historique:
received:
07
07
2021
revised:
23
12
2021
accepted:
21
02
2022
entrez:
16
3
2022
pubmed:
17
3
2022
medline:
12
4
2022
Statut:
ppublish
Résumé
The striatum mediates two learning modalities: goal-directed behavior in dorsomedial (DMS) and habits in dorsolateral (DLS) striata. The synaptic bases of these learnings are still elusive. Indeed, while ample research has described DLS plasticity, little remains known about DMS plasticity and its involvement in procedural learning. Here, we find symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in DMS and DLS, respectively, with opposite plasticity dominance upon increasing corticostriatal activity. During motor-skill learning, plasticity is engaged in DMS and striatonigral DLS neurons only during early learning stages, whereas striatopallidal DLS neurons are mobilized only during late phases. With a mathematical modeling approach, we find that symmetric anti-Hebbian STDP favors memory flexibility, while asymmetric anti-Hebbian STDP favors memory maintenance, consistent with memory processes at play in procedural learning.
Identifiants
pubmed: 35294877
pii: S2211-1247(22)00257-1
doi: 10.1016/j.celrep.2022.110521
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110521Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.