Chronic cocaine causes age-dependent increases in risky choice in both males and females.
Journal
Behavioral neuroscience
ISSN: 1939-0084
Titre abrégé: Behav Neurosci
Pays: United States
ID NLM: 8302411
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
pubmed:
18
3
2022
medline:
24
5
2022
entrez:
17
3
2022
Statut:
ppublish
Résumé
Individuals who use cocaine exhibit maladaptive decision-making, overweighting rewards, and underweighting potential risks. We previously showed that chronic cocaine self-administration in young adult male rats causes long-lasting increases in risk taking. The present study expanded upon these findings to determine whether effects of cocaine on risk taking depend on the route of cocaine administration and extend to females. To address the former question, rats in Experiment 1 were trained on the Risky Decision-making Task (RDT), received passively administered cocaine, and were retested in the RDT. Surprisingly, passive cocaine had no effect on risk taking. Experiment 2 determined whether cocaine self-administration increases risk taking in females in a manner comparable to males. Males and females were trained in the RDT, underwent cocaine self-administration, and were retested in the RDT. Unexpectedly, cocaine self-administration had no effect on risk taking in either sex. Because Experiments 1 and 2 involved cocaine exposure at a considerably older age than in previous work, Experiments 3 and 4 determined if cocaine effects on risk taking depend on the age of exposure. Rats began cocaine self-administration at postnatal (PN) day 77 (Experiment 3) or passive cocaine injections starting on PN day 63 (Experiment 4) and were tested in the RDT 3 weeks after cocaine cessation. In these experiments, cocaine increased risk taking in both sexes. These results reveal a limited time window during young adulthood of vulnerability to the effects of chronic cocaine on risk taking. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Identifiants
pubmed: 35298207
pii: 2022-43404-001
doi: 10.1037/bne0000509
pmc: PMC9346435
mid: NIHMS1825631
doi:
Substances chimiques
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-263Subventions
Organisme : NIDA NIH HHS
ID : R01 DA024671
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA041493
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA036534
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA041493
Pays : United States
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