Indazole-based microtubule-targeting agents as potential candidates for anticancer drugs discovery.

Antineoplastic Agents / chemistry Binding Sites Cell Line, Tumor Cell Proliferation Colchicine / metabolism Indazoles / metabolism Microtubules / metabolism Tubulin / metabolism Tubulin Modulators / chemistry
Anticancer Cancer Drug development Indazole Microtubule targeting agents Scaffold Tubulin

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
05 2022
Historique:
received: 21 10 2021
revised: 12 01 2022
accepted: 07 03 2022
pubmed: 18 3 2022
medline: 7 4 2022
entrez: 17 3 2022
Statut: ppublish

Résumé

Tremendous research is focused on developing novel drug candidates targeting microtubules to inhibit their function in several cellular processes, including cell division. In this regard, several indazole derivatives were sought to target the colchicine binding site on the β-tubulin, a crucial protein required to form microtubules, to develop microtubule targeting agents. Even though there are several reviews on the indazole-based compounds, none of them focused on using indazole scaffold to develop microtubule targeting agents. Therefore, this review aims to present the advances in research on compounds containing indazole scaffolds as microtubule targeting agents based on the articles published in the last two decades. Among the articles reviewed, we found that compounds 6 and 7 showed the lowest IC

Identifiants

DOI: 10.1016/j.bioorg.2022.105735 PMID: 35298962
pubmed: 35298962
pii: S0045-2068(22)00140-7
doi: 10.1016/j.bioorg.2022.105735
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Indazoles 0
Tubulin 0
Tubulin Modulators 0
Colchicine SML2Y3J35T

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105735

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Dilipkumar Pal (D)

Department of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya (A Central University), Bilaspur, Chhattisgarh 495009, India.

In-Ho Song (IH)

Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200702, South Korea.

Shrikant Dashrath Warkad (S)

Biometrix Technology, Inc., 2-2 Bio Venture Plaza 56, Chuncheon 24232, South Korea.

Keum-Soo Song (KS)

Biometrix Technology, Inc., 2-2 Bio Venture Plaza 56, Chuncheon 24232, South Korea.

Gyu Seong Yeom (G)

Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200702, South Korea.

Supriyo Saha (S)

School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Dehradun-248161, Uttarak-hand, India.

Pramod B Shinde (PB)

Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar 364002, Gujarat, India.

Satish Balasaheb Nimse (S)

Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200702, South Korea. Electronic address: satish_nimse@hallym.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Colchicine › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Indazole-based microtubule-targeting agents as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Modulateurs de la mitose › Modulateurs de la polymérisation de la tubuline › Indazole-based microtubule-targeting agents as...