BMPR1a Is Required for the Optimal TGFβ1-Dependent CD207
Animals
Antigens, CD
/ metabolism
Antigens, Surface
Bone Morphogenetic Protein Receptors, Type I
/ genetics
CD11 Antigens
CD11c Antigen
/ metabolism
Cell Differentiation
Dermatitis
/ metabolism
Epidermis
/ metabolism
Inflammation
/ metabolism
Langerhans Cells
/ metabolism
Lectins, C-Type
/ genetics
Mannose-Binding Lectins
/ metabolism
Mice
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
24
11
2021
revised:
08
02
2022
accepted:
21
02
2022
pubmed:
19
3
2022
medline:
24
8
2022
entrez:
18
3
2022
Statut:
ppublish
Résumé
The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and differentiation of LCs. LCs can be identified within the normal healthy human epidermis by anti-BMPR1a immunohistology staining. Deletion of BMPR1a in all (vav
Identifiants
pubmed: 35300973
pii: S0022-202X(22)00195-6
doi: 10.1016/j.jid.2022.02.014
pii:
doi:
Substances chimiques
Antigens, CD
0
Antigens, Surface
0
CD11 Antigens
0
CD11c Antigen
0
Cd207 protein, mouse
0
Itgax protein, mouse
0
Lectins, C-Type
0
Mannose-Binding Lectins
0
Bmpr1a protein, mouse
EC 2.7.11.30
Bone Morphogenetic Protein Receptors, Type I
EC 2.7.11.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2446-2454.e3Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.