Chaperoning heterochromatin: new roles of FACT in chromatin silencing.

Chromatin / genetics Euchromatin Gene Silencing Heterochromatin / genetics Histones / genetics
FACT H3K9 methylation heterochromatin spreading histone turnover

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
07 2022
Historique:
received: 07 01 2022
revised: 11 02 2022
accepted: 23 02 2022
pubmed: 20 3 2022
medline: 18 6 2022
entrez: 19 3 2022
Statut: ppublish

Résumé

The multitasking histone chaperone FACT (FAcilitates Chromatin Transcription) contributes to actively transcribed euchromatin and repressed heterochromatin. However, its precise role in gene silencing has remained obscure. Here, we discuss new insights into the silent chromatin functions and recruitment mechanisms of FACT, and their possible implications in cell identity and cancer.

Identifiants

DOI: 10.1016/j.tig.2022.02.011 PMID: 35303999
pubmed: 35303999
pii: S0168-9525(22)00038-5
doi: 10.1016/j.tig.2022.02.011
pii:
doi:

Substances chimiques

Chromatin 0
Euchromatin 0
Heterochromatin 0
Histones 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

646-649

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Magdalena Murawska (M)

Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany. Electronic address: magdalena.murawska@bmc.med.lmu.de.

Sigurd Braun (S)

Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany; Institute for Genetics, Justus-Liebig University Giessen, 35392 Giessen, Germany.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Chaperoning heterochromatin: new roles of FACT...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Euchromatine › Chaperoning heterochromatin: new roles of FACT...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Chaperoning heterochromatin: new roles of FACT...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Hétérochromatine › Chaperoning heterochromatin: new roles of FACT...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Chaperoning heterochromatin: new roles of FACT...