Translating pharmacology models effectively to predict therapeutic benefit.
Disease models
Efficacy
Nonclinical
PK/PD
Pharmacology
Translation
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
08
11
2021
revised:
03
02
2022
accepted:
11
03
2022
pubmed:
20
3
2022
medline:
25
5
2022
entrez:
19
3
2022
Statut:
ppublish
Résumé
Many in vitro and in vivo models are used in pharmacological research to evaluate the role of targeted proteins in a disease. Understanding the translational relevance and limitation of these models for analyzing a drug's disposition, pharmacokinetic/pharmacodynamic (PK/PD) profile, mechanism, and efficacy, is essential when selecting the most appropriate model of the disease of interest and predicting clinically efficacious doses of the investigational drug. Selected animal models used in ophthalmology, infectious diseases, oncology, autoimmune diseases, and neuroscience are reviewed here. Each area has specific challenges around translatability and determination of an efficacious dose: new patient-specific dosing methods may help overcome these limitations.
Identifiants
pubmed: 35304340
pii: S1359-6446(22)00117-9
doi: 10.1016/j.drudis.2022.03.009
pii:
doi:
Substances chimiques
Drugs, Investigational
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1604-1621Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.