Axel Paehler

Affiliations

Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

Publications (6)

Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers.

Expert opinion on investigational drugs

Avec: Michael Derks , Sian Lennon-Chrimes , Andreas Guenther , Lisa Squassante , Christoph Wandel , Piotr Szczesny , Axel Paehler , Heidemarie Kletzl

BET Inhibition Enhances TNF-Mediated Antitumor Immunity.

Cancer immunology research

Avec: Lisa C Wellinger , Simon J Hogg , Dane M Newman , Thomas Friess , Daniela Geiss , Jessica Michie , Kelly M Ramsbottom , Marina Bacac , Tanja Fauti , Daniel Marbach , Laura Jarassier , Phillip Thienger , Axel Paehler , Leonie A Cluse , Conor J Kearney , Stephin J Vervoort , Joseph A Trapani , Jane Oliaro , Jake Shortt , Astrid Ruefli-Brasse , Daniel Rohle , Ricky W Johnstone

Evaluation of the drug disposition of RO7049389 with in vitro data and human mass balance supported by physiologically based pharmacokinetic modelling.

British journal of clinical pharmacology

Avec: Yuchen Zhang , Kenichi Umehara , Andrea A Romeo , Nand Singh , Carina Cantrill , Mark Savage , Ethan Chen , Wen Zhang , Neil John Parrot , Axel Paehler

Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein.

Neuro-oncology

Avec: Holger Fischer , Mohammed Ullah , Cecile C de la Cruz , Thomas Hunsaker , Claudia Senn , Thomas Wirz , Björn Wagner , Dragomir Draganov , Faye Vazvaei , Massimiliano Donzelli , Axel Paehler , Mark Merchant , Li Yu

How Semiphysiological Population Pharmacokinetic Modeling Incorporating Active Hepatic Uptake Supports Phase II Dose Selection of RO7049389, A Novel Anti-Hepatitis B Virus Drug.

Clinical pharmacology and therapeutics

Avec: Valérie Cosson , Sheng Feng , Felix Jaminion , Annabelle Lemenuel-Diot , Neil Parrott , Axel Paehler , Qingyan Bo , Yuyan Jin

Translating pharmacology models effectively to predict therapeutic benefit.

Drug discovery today

Avec: Sherri Dudal , Caterina Bissantz , Antonello Caruso , Pascale David-Pierson , Wouter Driessen , Erich Koller , Ben-Fillippo Krippendorff , Martin Lechmann , Andrés Olivares-Morales , Axel Paehler , Caroline Rynn , Dietrich Türck , Arthur Van De Vyver , Ken Wang , Lotte Winther

Réseau de co-auteurs

Michael Derks 1 collaboration

Sian Lennon-Chrimes 1 collaboration

Andreas Guenther 1 collaboration

Lisa Squassante 1 collaboration

Christoph Wandel 1 collaboration

Piotr Szczesny 1 collaboration

Heidemarie Kletzl 1 collaboration

Lisa C Wellinger 1 collaboration

Simon J Hogg 1 collaboration

Dane M Newman 1 collaboration

Thomas Friess 1 collaboration

Daniela Geiss 1 collaboration

Jessica Michie 1 collaboration

Kelly M Ramsbottom 1 collaboration

Marina Bacac 1 collaboration

Tanja Fauti 1 collaboration

Daniel Marbach 1 collaboration

Laura Jarassier 1 collaboration

Phillip Thienger 1 collaboration

Leonie A Cluse 1 collaboration

Conor J Kearney 1 collaboration

Stephin J Vervoort 1 collaboration

Joseph A Trapani 1 collaboration

Jane Oliaro 1 collaboration

Jake Shortt 1 collaboration

Astrid Ruefli-Brasse 1 collaboration

Daniel Rohle 1 collaboration

Ricky W Johnstone 1 collaboration

Yuchen Zhang 1 collaboration

Kenichi Umehara 1 collaboration

Andrea A Romeo 1 collaboration

Nand Singh 1 collaboration

Carina Cantrill 1 collaboration

Mark Savage 1 collaboration

Ethan Chen 1 collaboration

Wen Zhang 1 collaboration

Neil John Parrot 1 collaboration

Holger Fischer 1 collaboration

Mohammed Ullah 1 collaboration

Cecile C de la Cruz 1 collaboration

Thomas Hunsaker 1 collaboration

Claudia Senn 1 collaboration

Thomas Wirz 1 collaboration

Björn Wagner 1 collaboration

Dragomir Draganov 1 collaboration

Faye Vazvaei 1 collaboration

Massimiliano Donzelli 1 collaboration

Mark Merchant 1 collaboration

Li Yu 1 collaboration

Valérie Cosson 1 collaboration

Sheng Feng 1 collaboration

Felix Jaminion 1 collaboration

Annabelle Lemenuel-Diot 1 collaboration

Neil Parrott 1 collaboration

Qingyan Bo 1 collaboration

Yuyan Jin 1 collaboration

Sherri Dudal 1 collaboration

Caterina Bissantz 1 collaboration

Antonello Caruso 1 collaboration

Pascale David-Pierson 1 collaboration

Wouter Driessen 1 collaboration

Erich Koller 1 collaboration

Ben-Fillippo Krippendorff 1 collaboration

Martin Lechmann 1 collaboration

Andrés Olivares-Morales 1 collaboration

Caroline Rynn 1 collaboration

Dietrich Türck 1 collaboration

Arthur Van De Vyver 1 collaboration

Ken Wang 1 collaboration

Lotte Winther 1 collaboration