Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study.
Abortion
Lamb mortality
Lamb survival
Parasite
Reproduction
Sheep
Toxoplasmosis
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
19 Mar 2022
19 Mar 2022
Historique:
received:
05
10
2021
accepted:
10
03
2022
entrez:
20
3
2022
pubmed:
21
3
2022
medline:
7
4
2022
Statut:
epublish
Résumé
Toxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to reproductive disease if T. gondii infection occurs during pregnancy. The aim of this study was to assess the impact of infection with T. gondii on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for T. gondii in Australian sheep. Toxoplasma gondii seropositivity using indirect ELISA was detected at 16/28 farms located across southern Australia. Apparent seropositivity to T. gondii was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5; P < 0.001). Toxoplasma gondii seroconversion during the gestation and lambing period was confirmed for 11/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy abortion. Low frequency of detection of T. gondii seroconversion during gestation and low frequency of seropositivity to T. gondii suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia.
Sections du résumé
BACKGROUND
BACKGROUND
Toxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to reproductive disease if T. gondii infection occurs during pregnancy. The aim of this study was to assess the impact of infection with T. gondii on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for T. gondii in Australian sheep.
RESULTS
RESULTS
Toxoplasma gondii seropositivity using indirect ELISA was detected at 16/28 farms located across southern Australia. Apparent seropositivity to T. gondii was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5; P < 0.001). Toxoplasma gondii seroconversion during the gestation and lambing period was confirmed for 11/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy abortion.
CONCLUSIONS
CONCLUSIONS
Low frequency of detection of T. gondii seroconversion during gestation and low frequency of seropositivity to T. gondii suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia.
Identifiants
pubmed: 35305646
doi: 10.1186/s12917-022-03211-w
pii: 10.1186/s12917-022-03211-w
pmc: PMC8933891
doi:
Substances chimiques
Antibodies, Protozoan
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109Informations de copyright
© 2022. The Author(s).
Références
Vet Parasitol. 2004 May 7;121(1-2):33-43
pubmed: 15110401
Vet Parasitol. 2007 Sep 1;148(2):122-9
pubmed: 17624672
Parasitology. 1995;110 Suppl:S11-6
pubmed: 7784124
Vet Res. 2011 Dec 21;42:121
pubmed: 22189159
Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101595
pubmed: 33260018
Prev Vet Med. 2021 Nov;196:105478
pubmed: 34487918
Aust Vet J. 2020 Dec 1;:
pubmed: 33289077
Aust Vet J. 1986 Nov;63(11):353-5
pubmed: 3548688
Parasitology. 2005 Mar;130(Pt 3):301-7
pubmed: 15796013
Aust Vet J. 2020 Nov;98(11):525-528
pubmed: 32779187
Parasitology. 2009 Dec;136(14):1887-94
pubmed: 19995468
Parasitol Res. 2021 Nov;120(11):3875-3882
pubmed: 34599357
Vet Pathol. 2021 Mar;58(2):346-360
pubmed: 33208021
Vet Pathol. 2021 Jan;58(1):114-122
pubmed: 33205699
Comp Immunol Microbiol Infect Dis. 2022 Jan;80:101727
pubmed: 34875542
Animals (Basel). 2021 Dec 21;12(1):
pubmed: 35011116
J Parasitol. 1989 Oct;75(5):673-6
pubmed: 2795369
Theriogenology. 2005 May;63(8):2075-88
pubmed: 15826674
N Z Vet J. 2011 Jul;59(4):155-9
pubmed: 21660843
Food Waterborne Parasitol. 2019 Apr 03;15:e00037
pubmed: 32095611
Aust Vet J. 2020 Jul;98(7):305-311
pubmed: 32253762
Parasitol Res. 2003 Sep;91(2):171-4
pubmed: 12923635
Int J Public Health. 2013 Oct;58(5):791-5
pubmed: 23263198
Vet Parasitol. 2009 Jul 7;163(1-2):1-14
pubmed: 19395175
N Z Vet J. 2004 Dec;52(6):371-7
pubmed: 15768138
Vet Parasitol. 2020 Oct;286:109195
pubmed: 32979682
Food Waterborne Parasitol. 2019 Apr 01;15:e00049
pubmed: 32095620
Vet Res. 2021 Jun 11;52(1):84
pubmed: 34116730
Vet Parasitol. 1995 Dec;60(3-4):241-7
pubmed: 8747907
Vet Res. 2016 Mar 16;47:43
pubmed: 26983883
Vet Parasitol. 2003 Nov 3;117(1-2):15-21
pubmed: 14597274