A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors.
Cone snail
Conotoxin
Conus archon
Mini M-conotoxin
Nicotinic acetylcholine receptor (nAChRs)
α7 nAChRs
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
31
08
2021
revised:
11
03
2022
accepted:
11
03
2022
pubmed:
22
3
2022
medline:
9
6
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
The venoms of Conus snails contain neuroactive peptides named conotoxins (CTXs). Some CTXs are nicotinic acetylcholine receptor (nAChRs) antagonists. nAChRs modulate the release of neurotransmitters and are implicated in several pathophysiologies. One venom peptide from Conus archon, a vermivorous species from the Mexican Pacific, was purified by RP-HPLC and its activity on human α7, α3β2, and α7β2 nAChRs was assessed by the two-electrode voltage clamp technique. At 36.3 µM the purified peptide (F27-1, renamed tentatively ArchIIIA) slowly reversibly inhibited the ACh-induced response of the hα7 subtype by 44.52 ± 5.83%, while it had low or no significant effect on the response of the hα3β2 and hα7β2 subtypes; the EC
Identifiants
pubmed: 35307452
pii: S0196-9781(22)00051-1
doi: 10.1016/j.peptides.2022.170785
pii:
doi:
Substances chimiques
Conotoxins
0
Nicotinic Antagonists
0
Peptides
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170785Informations de copyright
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