Plasma and bronchoalveolar lavage fluid oxylipin levels in experimental porcine lung injury.

Acute Lung Injury Animals Bronchoalveolar Lavage Fluid Dinoprostone Eicosanoids Oxylipins Swine
Biomarkers Inflammation Lung injury Mechanical ventilation Oxylipins Swine

Journal

Prostaglandins & other lipid mediators
ISSN: 1098-8823
Titre abrégé: Prostaglandins Other Lipid Mediat
Pays: United States
ID NLM: 9808648

Informations de publication

Date de publication:
06 2022
Historique:
received: 06 10 2021
revised: 13 03 2022
accepted: 15 03 2022
pubmed: 22 3 2022
medline: 20 5 2022
entrez: 21 3 2022
Statut: ppublish

Résumé

Inflammatory signaling pathways involving eicosanoids and other regulatory lipid mediators are a subject of intensive study, and a role for these in acute lung injury is not yet well understood. We hypothesized that oxylipin release from lung injury could be detected in bronchoalveolar lavage fluid and in plasma. In a porcine model of surfactant depletion, ventilation with hyperinflation was assessed. Bronchoalveolar lavage and plasma samples were analyzed for 37 different fatty acid metabolites (oxylipins). Over time, hyperinflation altered concentrations of 4 oxylipins in plasma (TXB

Identifiants

DOI: 10.1016/j.prostaglandins.2022.106636 PMID: 35307566
pubmed: 35307566
pii: S1098-8823(22)00026-0
doi: 10.1016/j.prostaglandins.2022.106636
pii:
doi:

Substances chimiques

Eicosanoids 0
Oxylipins 0
Dinoprostone K7Q1JQR04M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106636

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Niklas Larsson (N)

Anesthesiology and Intensive Care Medicine, Department of Surgical and Perioperative Sciences, Umeå University, 90185 Umeå, Sweden. Electronic address: niklas.larsson@regionvasterbotten.se.

Stefan Lehtipalo (S)

Anesthesiology and Intensive Care Medicine, Department of Surgical and Perioperative Sciences, Umeå University, 90185 Umeå, Sweden. Electronic address: stefan.lehtipalo@regionvasterbotten.se.

Sandra Gouveia-Figueira (S)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden. Electronic address: sandra.gouveia@regionvasterbotten.se.

Jonas Claesson (J)

Anesthesiology and Intensive Care Medicine, Department of Surgical and Perioperative Sciences, Umeå University, 90185 Umeå, Sweden. Electronic address: jonas.claesson@regionorebrolan.se.

Jamshid Pourazar (J)

Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, 90185 Umeå, Sweden. Electronic address: jamshid.pourazar@umu.se.

Martin Isaksson Mettävainio (M)

Pathology, Department of Medical Biosciences, Umeå University, 901 85 Umeå, Sweden. Electronic address: martin.isaksson.mettavainio@regionvasterbotten.se.

Michael Haney (M)

Anesthesiology and Intensive Care Medicine, Department of Surgical and Perioperative Sciences, Umeå University, 90185 Umeå, Sweden. Electronic address: michael.haney@umu.se.

Malin L Nording (ML)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden. Electronic address: malin.nording@umu.se.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Lésion pulmonaire aigüe › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Eucaryotes › Animaux › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Oxylipines › Plasma and bronchoalveolar lavage fluid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Plasma and bronchoalveolar lavage fluid...