Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.

Animals Anti-Bacterial Agents / chemistry Hydrazines / pharmacology Hydroxamic Acids / chemistry Mice Microbial Sensitivity Tests Molecular Docking Simulation Mycobacterium tuberculosis Structure-Activity Relationship
Antibacterial Antituberculous compounds Hydrazides Hydroxamic acids Mycobacterium tuberculosis

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 05 2022
Historique:
received: 24 10 2021
revised: 04 03 2022
accepted: 15 03 2022
pubmed: 22 3 2022
medline: 6 4 2022
entrez: 21 3 2022
Statut: ppublish

Résumé

With the aim to discover new antituberculous molecules, three novel series of 23 hydroxamic acids, 13 hydrazides, and 9O-alkyl/O-acyl protected hydroxamic acid derivatives have been synthesized, and fully characterized by spectral

Identifiants

DOI: 10.1016/j.bmcl.2022.128692 PMID: 35307568
pubmed: 35307568
pii: S0960-894X(22)00168-8
doi: 10.1016/j.bmcl.2022.128692
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Hydrazines 0
Hydroxamic Acids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

128692

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Vasiliki Mavrikaki (V)

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece. Electronic address: vmagriot@chem.uoa.gr.

Alexandros Pagonis (A)

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece.

Isabelle Poncin (I)

Aix-Marseille Univ, CNRS, LISM, IMM FR3479, Marseille, France.

Ivy Mallick (I)

Aix-Marseille Univ, CNRS, LISM, IMM FR3479, Marseille, France.

Stéphane Canaan (S)

Aix-Marseille Univ, CNRS, LISM, IMM FR3479, Marseille, France.

Victoria Magrioti (V)

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece.

Jean-François Cavalier (JF)

Aix-Marseille Univ, CNRS, LISM, IMM FR3479, Marseille, France. Electronic address: jfcavalier@imm.cnrs.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Acides hydroxamiques › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Design, synthesis and antibacterial activity...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, synthesis and antibacterial activity...