Protective effect of vanillin on the management of cecal ligation and puncture induced sepsis rat model.
Liver
Lung
Oxidative stress
Sepsis
Spleen
Survival
Vanillin
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
27
08
2021
revised:
06
01
2022
accepted:
16
03
2022
pubmed:
22
3
2022
medline:
15
4
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Present investigation evaluates the protective effect of vanillin against sepsis. Sepsis was induced by cecal ligation and puncture (CLP) in rat and vanillin was administered at dose of 100 and 200 mg/kg p.o. for five days after induction of sepsis. Effect of vanillin was observed on the percentage of survival, body weight and food intake were determined in CLP induced sepsis rats. Level of liver enzymes in the serum and organ weight was also observed in vanillin treated CLP induced rats. Moreover, histopathological changes were also observed in liver and lung tissue of hematoxylin and eosin (H&E) staining. There was significant improvement in bodyweight and food intake in vanillin treated group than negative control group after the sepsis induction. Moreover, vanillin improves the percentage of survival rate and reduces the level of liver enzymes and spleen weight in CLP induced sepsis rat. It also improves the level of glutathione (GSH) compared to negative control group. In conclusion, data of investigation reveals that vanillin ameliorates the survival rate and oxidative stress in CLP induced sepsis rat model.
Identifiants
pubmed: 35307600
pii: S0882-4010(22)00106-1
doi: 10.1016/j.micpath.2022.105493
pii:
doi:
Substances chimiques
Benzaldehydes
0
vanillin
CHI530446X
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105493Informations de copyright
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