QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment.
QPCTL
cancer-associated fibroblasts
genetically modified mouse model
tumor micro-environment
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH
Identifiants
pubmed: 35309731
doi: 10.1080/2162402X.2022.2049486
pii: 2049486
pmc: PMC8932921
doi:
Substances chimiques
CD47 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2049486Subventions
Organisme : European Research Council
ID : 742259
Pays : International
Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
M.E.W.L. and T.N.S. are inventors on a patent application that covers manipulation of the CD47-SIRPα axis via QPCTL. M.E.W.L. is a consultant for Third Rock Ventures, outside of this work. T.N.S. is advisor to and holds equity in Scenic Biotech that develops QPCTL inhibitors. T.N.S. is consultant for Third Rock Ventures and advisor to and stockholder in Allogene Therapeutics, Asher Bio, Merus, and Neogene Therapeutics, all outside of this work.
Références
BMC Genomics. 2018 Jun 19;19(1):477
pubmed: 29914354
BMC Bioinformatics. 2009 Apr 09;10:106
pubmed: 19358741
Nat Immunol. 2005 Jun;6(6):600-7
pubmed: 15852008
J Photochem Photobiol B. 2016 Oct;163:133-43
pubmed: 27567084
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2301-6
pubmed: 24474804
Nature. 2018 Feb 22;554(7693):538-543
pubmed: 29443964
Cell Res. 2020 Sep;30(9):745-762
pubmed: 32561858
Alzheimers Dement (N Y). 2015 Oct 03;1(3):182-195
pubmed: 29854937
Pigment Cell Melanoma Res. 2014 Mar;27(2):201-8
pubmed: 24267286
J Immunother Cancer. 2019 Apr 8;7(1):100
pubmed: 30961656
Nat Commun. 2020 Mar 5;11(1):1201
pubmed: 32139671
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4239-44
pubmed: 22371602
Cell Rep. 2016 Nov 22;17(9):2445-2459
pubmed: 27840052
Cell. 2009 Jul 23;138(2):271-85
pubmed: 19632178
Mol Cell. 2008 Jul 25;31(2):266-77
pubmed: 18657508
Biosci Rep. 2017 Aug 23;37(4):
pubmed: 28739588
Nucleic Acids Res. 2014 Dec 16;42(22):e168
pubmed: 25300484
Cell Rep. 2018 May 1;23(5):1239-1248
pubmed: 29719241
J Am Soc Nephrol. 2019 May;30(5):767-781
pubmed: 30948627
Cell. 2021 Feb 4;184(3):792-809.e23
pubmed: 33545035
Cancer Cell. 2005 Nov;8(5):369-80
pubmed: 16286245
Cell. 2018 Nov 1;175(4):1014-1030.e19
pubmed: 30343900
J Exp Med. 2017 Mar 6;214(3):579-596
pubmed: 28232471
Commun Biol. 2021 Nov 17;4(1):1296
pubmed: 34789823
J Biol Chem. 2012 May 25;287(22):18806-19
pubmed: 22493489
Nat Med. 2019 Apr;25(4):612-619
pubmed: 30833751
Nat Biotechnol. 2019 Aug;37(8):907-915
pubmed: 31375807
Cancer Discov. 2019 Aug;9(8):1102-1123
pubmed: 31197017
Nat Immunol. 2019 Aug;20(8):1012-1022
pubmed: 31263276
FEBS J. 2009 Nov;276(22):6522-36
pubmed: 19804409
Cancer Discov. 2016 Dec;6(12):1366-1381
pubmed: 27683557
EMBO Mol Med. 2011 Sep;3(9):545-58
pubmed: 21774078
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Nat Methods. 2021 Oct;18(10):1181-1191
pubmed: 34594031
Semin Immunol. 2020 Apr;48:101417
pubmed: 33077325
Biochem J. 2012 Mar 1;442(2):403-12
pubmed: 22060158
Genome Biol. 2019 Oct 11;20(1):206
pubmed: 31604482
Gastroenterology. 2019 Nov;157(5):1352-1367.e13
pubmed: 31362006
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Nat Immunol. 2014 Sep;15(9):846-55
pubmed: 25086775
Nat Rev Immunol. 2020 Dec;20(12):771-780
pubmed: 32612208
J Mol Biol. 2008 Jun 20;379(5):966-80
pubmed: 18486145
Biol Chem. 2016 Jan;397(1):45-55
pubmed: 26351917
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
Cell. 2009 Jul 23;138(2):286-99
pubmed: 19632179
PLoS Biol. 2010 Apr 27;8(4):e1000361
pubmed: 20436908
Nat Chem Biol. 2015 May;11(5):347-354
pubmed: 25848931
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18342-7
pubmed: 22042861
Nat Commun. 2019 Sep 25;10(1):4353
pubmed: 31554795
Cancer Discov. 2016 Jan;6(1):71-9
pubmed: 26493961
J Biol Chem. 2003 Dec 12;278(50):49773-9
pubmed: 14522962
Nanotheranostics. 2021 Jan 1;5(1):36-56
pubmed: 33391974
Eur J Immunol. 2014 Aug;44(8):2247-62
pubmed: 24796276
Nat Biomed Eng. 2019 Oct;3(10):796-805
pubmed: 31548591