Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases.
AlkZ
DNA cross-link
DNA glycosylase
DNA repair
HTH_42
Streptomyces
biosynthetic gene cluster
genotoxin
intecalator
natural product
phylogenetic tree
secondary metabolism
self-resistance
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
26 04 2022
26 04 2022
Historique:
pubmed:
22
3
2022
medline:
29
4
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs). Among these, the DNA glycosylase AlkZ is essential for azinomycin B production and belongs to the HTH_42 superfamily of uncharacterized proteins. Despite their widespread existence in antibiotic producers and pathogens, the roles of these proteins in production of other natural products are unknown. Here, we determine the evolutionary relationship and genomic distribution of all HTH_42 proteins from
Identifiants
pubmed: 35311535
doi: 10.1128/mbio.03297-21
pmc: PMC9040887
doi:
Substances chimiques
Alkylating Agents
0
Anti-Bacterial Agents
0
Biological Products
0
DNA Adducts
0
Mutagens
0
DNA
9007-49-2
DNA Glycosylases
EC 3.2.2.-
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0329721Subventions
Organisme : HHS | National Institutes of Health (NIH)
ID : R01GM131071
Organisme : Howard Hughes Medical Institute (HHMI)
Organisme : National Science Foundation (NSF)
ID : MCB-1928918
Organisme : NIEHS NIH HHS
ID : T32 ES007028
Pays : United States
Organisme : National Science Foundation (NSF)
ID : DGE-1445197
Organisme : National Science Foundation (NSF)
ID : DEB-1442113
Organisme : HHS | National Institutes of Health (NIH)
ID : T32ES007028
Références
Nature. 1966 Jan 29;209(5022):481-4
pubmed: 4958487
Nucleic Acids Res. 2020 Jan 8;48(D1):D454-D458
pubmed: 31612915
J Bacteriol. 1995 Oct;177(19):5393-400
pubmed: 7559321
Nucleic Acids Res. 2016 Jan 8;44(1):187-97
pubmed: 26400161
J Antibiot (Tokyo). 1990 Mar;43(3):253-8
pubmed: 2324010
J Mol Biol. 2008 Aug 1;381(1):13-23
pubmed: 18585735
J Antibiot (Tokyo). 2009 Jan;62(1):5-16
pubmed: 19132062
Mol Cancer Ther. 2007 Oct;6(10):2708-18
pubmed: 17938264
Nucleic Acids Res. 2019 Jan 8;47(D1):D427-D432
pubmed: 30357350
Cell Chem Biol. 2021 Dec 16;28(12):1703-1715.e11
pubmed: 34293284
J Antibiot (Tokyo). 1990 Apr;43(4):417-21
pubmed: 2161819
Bioinformatics. 2009 Jun 1;25(11):1422-3
pubmed: 19304878
Acta Biochim Biophys Sin (Shanghai). 2020 Jan 2;52(1):91-96
pubmed: 31833535
Chem Biol. 2014 Aug 14;21(8):923-34
pubmed: 25041948
Mol Microbiol. 2006 Mar;59(5):1602-9
pubmed: 16468998
EMBO J. 1998 Nov 16;17(22):6730-8
pubmed: 9890793
Trends Microbiol. 2017 Apr;25(4):280-292
pubmed: 28038926
Cell Chem Biol. 2017 Oct 19;24(10):1194-1195
pubmed: 29053949
Nat Chem Biol. 2017 Sep;13(9):1002-1008
pubmed: 28759018
Nature. 2019 Feb;566(7742):94-99
pubmed: 30728519
J Bacteriol. 1996 Jun;178(11):3238-45
pubmed: 8655504
Nucleic Acids Res. 2020 Jul 27;48(13):7005-7017
pubmed: 32409837
Chem Rev. 2012 Mar 14;112(3):1681-709
pubmed: 22017381
Chem Res Toxicol. 2009 Nov;22(11):1747-60
pubmed: 19757819
Cell. 2003 Apr 18;113(2):183-93
pubmed: 12705867
Nat Rev Mol Cell Biol. 2016 Oct;17(10):659-73
pubmed: 27534801
Nucleic Acids Res. 2008 Jun;36(10):3508-14
pubmed: 18453630
Mol Microbiol. 1993 Jul;9(1):119-31
pubmed: 8412657
Molecules. 2020 Nov 17;25(22):
pubmed: 33212836
J Bacteriol. 2002 Nov;184(22):6115-22
pubmed: 12399480
Chem Biol. 2008 Jul 21;15(7):693-705
pubmed: 18635006
mSystems. 2019 May 14;4(4):
pubmed: 31098395
Nature. 2018 Jul;559(7714):415-418
pubmed: 29995859
Nucleic Acids Res. 2015 Nov 16;43(20):9645-62
pubmed: 26442528
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4400-4405
pubmed: 28396405
Bioorg Med Chem. 1997 Feb;5(2):263-76
pubmed: 9061191
Biochim Biophys Acta. 2013 Jan;1834(1):247-71
pubmed: 23076011
J Biochem. 1967 Sep;62(3):321-7
pubmed: 4869973
Biochemistry. 2015 Jan 27;54(3):898-908
pubmed: 25537480
Chem Rev. 2005 Feb;105(2):739-58
pubmed: 15700963
Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10532-6
pubmed: 22987648
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10961-E10969
pubmed: 30373830
Braz J Infect Dis. 2012 Sep-Oct;16(5):466-71
pubmed: 22975171
J Antibiot (Tokyo). 1981 Dec;34(12):1519-24
pubmed: 6895890
Nucleic Acids Res. 2019 Jul 2;47(W1):W256-W259
pubmed: 30931475
Nucleic Acids Res. 2022 Mar 21;50(5):2417-2430
pubmed: 35191495
Mutat Res. 1996 Oct 28;358(1):81-7
pubmed: 8921978
Nat Chem Biol. 2020 Nov;16(11):1189-1198
pubmed: 32572277
Chem Biol. 1995 Apr;2(4):229-40
pubmed: 9383425
Cancer Res. 1997 Oct 15;57(20):4564-9
pubmed: 9377570
EMBO J. 2018 Jan 4;37(1):63-74
pubmed: 29054852
Genome Res. 2004 Jun;14(6):1188-90
pubmed: 15173120
Nucleic Acids Res. 2021 Apr 19;49(7):3876-3887
pubmed: 33744958
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Nucleic Acids Res. 2019 Jul 2;47(W1):W636-W641
pubmed: 30976793
Chem Sci. 2015 Jun 1;6(6):3440-3447
pubmed: 29511509
Curr Opin Microbiol. 2018 Oct;45:100-108
pubmed: 29642052
Nat Prod Bioprospect. 2021 Feb;11(1):5-13
pubmed: 33389713
J Mol Biol. 2016 Feb 22;428(4):726-731
pubmed: 26585406
Nat Biotechnol. 2013 Oct;31(10):922-7
pubmed: 24056948
J Ind Microbiol Biotechnol. 2010 Jul;37(7):643-72
pubmed: 20446033
J Biol Chem. 2013 May 17;288(20):14125-14134
pubmed: 23549043
Nat Prod Rep. 2016 Aug 27;33(8):988-1005
pubmed: 27272205
J Antibiot (Tokyo). 1981 Dec;34(12):1525-30
pubmed: 6800996
Mol Microbiol. 2019 Feb;111(2):338-353
pubmed: 30379365
Trends Biochem Sci. 2019 Sep;44(9):765-781
pubmed: 31078398
Chem Res Toxicol. 2004 Jul;17(7):942-9
pubmed: 15257620
Biochemistry. 1977 Jul 26;16(15):3406-12
pubmed: 329871
Nat Commun. 2021 Nov 26;12(1):6942
pubmed: 34836957
Brief Bioinform. 2019 Jul 19;20(4):1160-1166
pubmed: 28968734
J Bacteriol. 1999 Nov;181(21):6763-71
pubmed: 10542179
Nucleic Acids Res. 2002 May 15;30(10):2212-23
pubmed: 12000841
Mol Cells. 2001 Feb 28;11(1):41-7
pubmed: 11266119
Nucleic Acids Res. 2020 Jul 2;48(W1):W546-W552
pubmed: 32427317
J Am Chem Soc. 2016 Sep 14;138(36):11485-8
pubmed: 27571247
Sci Rep. 2020 Feb 6;10(1):2003
pubmed: 32029878
J Biol Chem. 2004 Mar 12;279(11):9750-7
pubmed: 14688248
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2281-5
pubmed: 8460134
Nat Rev Genet. 2009 Aug;10(8):551-64
pubmed: 19597530
Chem Biol Interact. 1989;70(3-4):289-303
pubmed: 2743474
Chem Sci. 2018 May 3;9(21):4898-4908
pubmed: 29910943
Nat Rev Microbiol. 2017 Jul 24;15(10):629
pubmed: 28736449
Mol Cancer Ther. 2004 May;3(5):577-85
pubmed: 15141015
Methods. 2013 Nov;64(1):59-66
pubmed: 23876937
Nucleic Acids Res. 2019 Jan 8;47(D1):D309-D314
pubmed: 30418610
Nucleic Acids Res. 2019 Jul 2;47(W1):W81-W87
pubmed: 31032519
J Am Chem Soc. 2003 Sep 10;125(36):10971-6
pubmed: 12952479