Determination of diagnostic threshold in harmonization and comparison of clinical utility for five major antiphospholipid antibody assays used in Japan.
anti-β2-glycoprotein I antibodies
anticardiolipin antibodies
antiphospholipid antibodies
diagnostic threshold
method comparison
Journal
Journal of clinical laboratory analysis
ISSN: 1098-2825
Titre abrégé: J Clin Lab Anal
Pays: United States
ID NLM: 8801384
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
20
01
2022
received:
13
10
2021
accepted:
26
02
2022
pubmed:
22
3
2022
medline:
18
5
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Anticardiolipin antibodies (aCL) and anti-β We evaluated two manual and three automated assays for aCL and aβ A variable degree of discrepancy between URLs and the cutoff values was observed, which was partly attributable to between-year assay variability. 97.5%URLs were set lower and closer to the cutoff values than 99%URLs. For all assays, diagnostic accuracies of both aβ To ensure harmonized APS diagnosis, the diagnostic thresholds of the five assays were evaluated by common procedures. Contrary to the guideline, 97.5%URL is rather recommended for diagnosing APS, which showed a closer match to the cutoff value.
Sections du résumé
BACKGROUND
BACKGROUND
Anticardiolipin antibodies (aCL) and anti-β
METHODS
METHODS
We evaluated two manual and three automated assays for aCL and aβ
RESULTS
RESULTS
A variable degree of discrepancy between URLs and the cutoff values was observed, which was partly attributable to between-year assay variability. 97.5%URLs were set lower and closer to the cutoff values than 99%URLs. For all assays, diagnostic accuracies of both aβ
CONCLUSION
CONCLUSIONS
To ensure harmonized APS diagnosis, the diagnostic thresholds of the five assays were evaluated by common procedures. Contrary to the guideline, 97.5%URL is rather recommended for diagnosing APS, which showed a closer match to the cutoff value.
Identifiants
pubmed: 35312119
doi: 10.1002/jcla.24340
pmc: PMC9102671
doi:
Substances chimiques
Antibodies, Anticardiolipin
0
Antibodies, Antiphospholipid
0
Autoantibodies
0
Immunoglobulin G
0
Immunoglobulin M
0
beta 2-Glycoprotein I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24340Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K07468
Informations de copyright
© 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
Références
Thromb Res. 2019 Sep;181:52-58
pubmed: 31351266
Thromb Res. 2014 Jun;133(6):1135-40
pubmed: 24721837
Lancet. 2010 Oct 30;376(9751):1498-509
pubmed: 20822807
Clin Chem Lab Med. 2013 Jul;51(7):1429-42
pubmed: 23435151
Blood. 2011 Sep 8;118(10):2774-83
pubmed: 21757614
Arthritis Rheum. 1997 Sep;40(9):1725
pubmed: 9324032
Blood. 2010 Aug 26;116(8):1336-43
pubmed: 20462962
Haematologica. 2006 May;91(5):699-702
pubmed: 16627257
Semin Thromb Hemost. 2008 Apr;34(3):236-50
pubmed: 18720303
Thromb Res. 2016 Oct;146:1-6
pubmed: 27552227
Clin Exp Rheumatol. 2013 May-Jun;31(3):382-8
pubmed: 23305633
J Thromb Haemost. 2006 Feb;4(2):295-306
pubmed: 16420554
J Clin Lab Anal. 2022 May;36(5):e24340
pubmed: 35312119
Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(5):430-6
pubmed: 25744643
Arthritis Rheum. 2000 Sep;43(9):1982-93
pubmed: 11014348
Lupus. 1996 Oct;5(5):431-5
pubmed: 8902775
J Dermatol Sci. 2017 Mar;85(3):208-215
pubmed: 28012821
Clin Chem Lab Med. 2010 Nov;48(11):1537-51
pubmed: 21062226