A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
10
03
2022
received:
12
11
2021
accepted:
14
03
2022
pubmed:
22
3
2022
medline:
23
9
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4 We show that vaccinating with ChAd-Gt1-6 and E2Δ123 These data are an important step forward for the development of a pan-genotype HCV vaccine to elicit T cells and nAbs for future assessment in humans.
Sections du résumé
BACKGROUND AND AIMS
A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4
APPROACH AND RESULTS
We show that vaccinating with ChAd-Gt1-6 and E2Δ123
CONCLUSIONS
These data are an important step forward for the development of a pan-genotype HCV vaccine to elicit T cells and nAbs for future assessment in humans.
Identifiants
pubmed: 35313015
doi: 10.1002/hep.32470
pmc: PMC9790311
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Epitopes
0
Hepatitis C Antibodies
0
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1190-1202Subventions
Organisme : Medical Research Council
ID : G0901723
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17174
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K010239/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : 1146082
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. Hepatology published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.
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