Metabolic Activation and Cytotoxicity of Fungicide Carbendazim Mediated by CYP1A2.

Activation, Metabolic Animals Benzimidazoles Carbamates / metabolism Cytochrome P-450 CYP1A2 / metabolism Glutathione / metabolism Microsomes, Liver / metabolism Rats Zebrafish / metabolism
carbendazim liver injury quinone-imine

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
06 Apr 2022
Historique:
pubmed: 23 3 2022
medline: 8 4 2022
entrez: 22 3 2022
Statut: ppublish

Résumé

Carbendazim (CBZ) is a broad-spectrum fungicide widely used in many nations for foliar spray as well as seed and soil treatment. The resulting contamination and environmental pollution have been drawing public attention. In particular, CBZ was reported to cause liver damage in rats and zebrafish, and the mechanisms of its toxicity have not been clarified. The purposes of this study were to investigate the metabolic activation of CBZ and to determine a possible role of the reactive metabolites in CBZ-induced liver injury reported. One oxidative metabolite (M1), one glutathione conjugate (M2), and one

Identifiants

DOI: 10.1021/acs.jafc.1c08144 PMID: 35316061
pubmed: 35316061
doi: 10.1021/acs.jafc.1c08144
doi:

Substances chimiques

Benzimidazoles 0
Carbamates 0
Cytochrome P-450 CYP1A2 EC 1.14.14.1
Glutathione GAN16C9B8O
carbendazim H75J14AA89

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4092-4101

Auteurs

Junzu Shi (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Min Zhao (M)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Kaixuan Li (K)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Yanjia Zhao (Y)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Wei Li (W)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Ying Peng (Y)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Jiang Zheng (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.
Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.
ORCID: 0000-0002-8187-2147

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Activation métabolique › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Carbamates › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1A2 › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Metabolic Activation and Cytotoxicity of...