Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity.
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemical synthesis
Heterocyclic Compounds
/ chemical synthesis
Histone Demethylases
/ antagonists & inhibitors
Humans
Molecular Structure
Monoamine Oxidase
/ metabolism
Structure-Activity Relationship
Tranylcypromine
/ chemical synthesis
Tumor Cells, Cultured
Epigenetics
anticancer activity
histone demethylase
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
29
3
2022
Statut:
ppublish
Résumé
As regioisomers/bioisosteres of
Identifiants
pubmed: 35317680
doi: 10.1080/14756366.2022.2052869
pmc: PMC8942502
doi:
Substances chimiques
Antineoplastic Agents
0
Enzyme Inhibitors
0
Heterocyclic Compounds
0
Tranylcypromine
3E3V44J4Z9
Histone Demethylases
EC 1.14.11.-
Monoamine Oxidase
EC 1.4.3.4
monoamine oxidase A, human
EC 1.4.3.4.
KDM1A protein, human
EC 1.5.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
973-985Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114306
Pays : United States
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