Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling.
M2 macrophage
experimental pulmonary hypertension
fibroblast growth factor
periostin
vascular remodelling
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
29
01
2022
received:
28
09
2021
accepted:
08
03
2022
pubmed:
24
3
2022
medline:
22
6
2022
entrez:
23
3
2022
Statut:
ppublish
Résumé
Remodelling of pulmonary arteries (PA) contributes to the progression of pulmonary hypertension (PH). Periostin, a matricellular protein, has been reported to be involved in the development of PH. We examined the role of periostin in the pathogenesis of PH using different types of experimental PH. PH was induced by vascular endothelial growth factor receptor antagonist (Sugen5416) plus hypoxic exposure (SuHx) and venous injection of monocrotaline-pyrrole (MCT-P) in wild-type (WT) and periostin In PH induced by SuHx and MCT-P, PH and accumulation of M2 macrophage to small PA were attenuated in periostin Periostin is involved in the development of different types of experimental PH, and may also contribute to the pathogenesis of human PH.
Sections du résumé
BACKGROUND AND OBJECTIVE
Remodelling of pulmonary arteries (PA) contributes to the progression of pulmonary hypertension (PH). Periostin, a matricellular protein, has been reported to be involved in the development of PH. We examined the role of periostin in the pathogenesis of PH using different types of experimental PH.
METHODS
PH was induced by vascular endothelial growth factor receptor antagonist (Sugen5416) plus hypoxic exposure (SuHx) and venous injection of monocrotaline-pyrrole (MCT-P) in wild-type (WT) and periostin
RESULTS
In PH induced by SuHx and MCT-P, PH and accumulation of M2 macrophage to small PA were attenuated in periostin
CONCLUSION
Periostin is involved in the development of different types of experimental PH, and may also contribute to the pathogenesis of human PH.
Identifiants
pubmed: 35318760
doi: 10.1111/resp.14249
pmc: PMC9313806
doi:
Substances chimiques
Cell Adhesion Molecules
0
Postn protein, mouse
0
Vascular Endothelial Growth Factor A
0
Fibroblast Growth Factor 2
103107-01-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-538Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148165
Pays : United States
Informations de copyright
© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.
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