Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
25 03 2022
25 03 2022
Historique:
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
7
4
2022
Statut:
ppublish
Résumé
Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.
Identifiants
pubmed: 35319982
doi: 10.1126/sciadv.abk1410
pmc: PMC8942377
doi:
Substances chimiques
Venoms
0
Somatostatin
51110-01-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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