microRNA expression levels in the nucleus accumbens correlate with morphine-taking but not morphine-seeking behaviour in male rats.
craving
noncoding RNA
opioids
relapse
self-administration
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
04
03
2022
received:
09
12
2021
accepted:
15
03
2022
pubmed:
24
3
2022
medline:
14
4
2022
entrez:
23
3
2022
Statut:
ppublish
Résumé
A powerful motivation to seek opioids remains after drug cessation and intensifies during extended periods of abstinence. Unfortunately, biomarkers associated with continued drug seeking have not been described. Moreover, previous studies have focused on the effects of early abstinence with little exploration into the long-term drug-induced mechanisms that occur after extended abstinence. Here we demonstrated that 30 days (D) of forced abstinence results in a time-dependent increase in morphine seeking in a rat model of morphine self-administration (SA). We measured expression of known drug-responsive microRNAs (miRNAs) in the nucleus accumbens, an area critical for reward-related plasticity, during early or late abstinence in animals that underwent either a cue-induced relapse test or no relapse test. miRNAs are small noncoding RNAs that represent suitable biomarker candidates due to their long-lasting nature. mir-32-5p levels during early abstinence negatively correlated with active lever pressing in both cue-exposed and cue-naïve animals. mir-1298-5p positively correlated with drug SA history after a relapse test during late abstinence. When animals underwent acute abstinence with no relapse test, mir-1298-5p correlated with drug infusions and active lever pressing during SA. In late abstinence with no relapse test, mir-137-3p negatively correlated with drug infusions. Regulation of mir-32-5p target genes and significant correlation of target gene mRNA with mir-32-5p was observed after abstinence. These results indicate that lasting regulation of miRNA expression is associated with drug intake following morphine SA. In addition, we conclude that the miRNA profile undergoes regulation from early to late abstinence and miRNA expression may indicate past drug history.
Identifiants
pubmed: 35320877
doi: 10.1111/ejn.15650
pmc: PMC9314918
doi:
Substances chimiques
MIRN137 microRNA, rat
0
MicroRNAs
0
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1742-1755Subventions
Organisme : NIDA NIH HHS
ID : R00 DA041469
Pays : United States
Organisme : NIDA NIH HHS
ID : P30 DA013429
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA039308
Pays : United States
Organisme : NIDA NIH HHS
ID : DP1 DA046537
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007237
Pays : United States
Informations de copyright
© 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Nucleic Acids Res. 2019 Jan 8;47(D1):D155-D162
pubmed: 30423142
Nature. 2010 Jul 8;466(7303):197-202
pubmed: 20613834
Sci Rep. 2021 Jul 21;11(1):14825
pubmed: 34290298
Biol Psychiatry. 2013 Apr 15;73(8):729-37
pubmed: 23384483
J Neurosci. 2014 Mar 26;34(13):4581-8
pubmed: 24672003
FASEB J. 2013 Feb;27(2):522-35
pubmed: 23085997
Mol Pharmacol. 2014 Feb;85(2):368-80
pubmed: 24302561
J Physiol. 2012 May 15;590(10):2427-42
pubmed: 22393250
Addict Biol. 2011 Apr;16(2):261-72
pubmed: 21182575
J Immunol. 2015 Feb 1;194(3):1021-30
pubmed: 25539811
Int J Mol Sci. 2017 Sep 16;18(9):
pubmed: 28926935
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):154-60
pubmed: 23726802
Genome Res. 2009 Jan;19(1):92-105
pubmed: 18955434
J Neuroimmune Pharmacol. 2016 Sep;11(3):542-8
pubmed: 27108111
Neural Regen Res. 2018 Jan;13(1):77-85
pubmed: 29451210
Methods Mol Biol. 2014;1182:265-77
pubmed: 25055918
J Neurosci. 2010 Jul 28;30(30):10251-8
pubmed: 20668208
Addict Biol. 2019 Jul;24(4):604-616
pubmed: 29665166
Trends Neurosci. 2011 Aug;34(8):411-20
pubmed: 21764143
Psychopharmacology (Berl). 2021 Aug;238(8):2313-2324
pubmed: 33932163
Neuropharmacology. 2017 Feb;113(Pt A):271-280
pubmed: 27729240
J Neurosci. 2013 Mar 20;33(12):5127-37
pubmed: 23516279
Eur J Neurosci. 2022 Apr;55(7):1742-1755
pubmed: 35320877
Biol Psychiatry. 2013 Oct 1;74(7):511-9
pubmed: 23702428
Behav Neurosci. 2010 Dec;124(6):828-38
pubmed: 21038934
Int J Neuropsychopharmacol. 2019 Jun 3;22(6):383-393
pubmed: 30989210
PLoS One. 2019 Jan 10;14(1):e0209846
pubmed: 30629705
Neurosci Bull. 2016 Dec;32(6):512-522
pubmed: 27628529
Addict Biol. 2018 Mar;23(2):631-642
pubmed: 28612502
Physiol Rev. 2019 Oct 1;99(4):2115-2140
pubmed: 31507244
Nature. 2001 Jul 12;412(6843):141-2
pubmed: 11449260
Addict Biol. 2013 May;18(3):480-95
pubmed: 22804800
Am J Addict. 2014 Sep-Oct;23(5):453-8
pubmed: 24628912
Mol Cell. 2019 Aug 22;75(4):756-768.e7
pubmed: 31350118
NCHS Data Brief. 2020 Dec;(394):1-8
pubmed: 33395384
Mol Psychiatry. 2018 Feb;23(2):434-443
pubmed: 28044061
Exp Ther Med. 2018 Apr;15(4):3369-3375
pubmed: 29545857
J Neurosci. 2020 Mar 18;40(12):2485-2497
pubmed: 32051327
BMC Genomics. 2019 Nov 13;20(1):849
pubmed: 31722663
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11650-5
pubmed: 21697510
Sci Rep. 2017 Jan 11;7:40413
pubmed: 28074855
Mol Pharmacol. 2010 Nov;78(5):935-42
pubmed: 20716624
West J Med. 1980 Nov;133(5):383-91
pubmed: 7008358
Front Behav Neurosci. 2020 Aug 28;14:153
pubmed: 33088264
Addict Biol. 2021 Mar;26(2):e12927
pubmed: 32570285
Science. 2007 Dec 21;318(5858):1931-4
pubmed: 18048652
Biomarkers. 2015 Mar;20(2):123-31
pubmed: 25598229
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Eur J Neurosci. 2012 Oct;36(7):2941-8
pubmed: 22845676
Neuropsychopharmacology. 2022 Feb 21;:
pubmed: 35190706
Mol Pharmacol. 2009 Apr;75(4):744-50
pubmed: 19144786
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Drug Alcohol Depend. 2011 Nov 1;118(2-3):251-8
pubmed: 21549528
J Pharmacol Exp Ther. 2019 May;369(2):244-258
pubmed: 30867225
Drug Alcohol Depend. 2021 Aug 1;225:108755
pubmed: 34052686
Pharmacol Biochem Behav. 2009 Dec;94(2):262-70
pubmed: 19751755
Mol Pain. 2016 Sep 05;12:
pubmed: 27599867
RNA. 2009 Jan;15(1):21-32
pubmed: 19029310
J Neurosci. 2010 Jun 16;30(24):8102-10
pubmed: 20554861