The profile of urinary lipid metabolites in healthy dogs.
dog
lipid metabolite
urine
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
pubmed:
25
3
2022
medline:
4
5
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body. We comprehensively analyzed lipid metabolites in dog urine using a liquid chromatograph-mass spectrometry (LC-MS/MS) to describe their metabolic characteristics. We detected 31 AA-derived metabolites, four EPA-derived metabolites, and a DHA-derived metabolite in all urine samples. Among AA-derived metabolites, 15, 5, 3, and 8 were generated by COX, LOX, CYP, and non-enzymatic oxidation respectively. This study will be the first step to use profiles of urinary lipid metabolites for better understanding and diagnosis of canine diseases.
Identifiants
pubmed: 35321995
doi: 10.1292/jvms.22-0020
pmc: PMC9177396
doi:
Substances chimiques
Eicosanoids
0
Docosahexaenoic Acids
25167-62-8
Arachidonic Acid
27YG812J1I
Cytochrome P-450 Enzyme System
9035-51-2
Eicosapentaenoic Acid
AAN7QOV9EA
Prostaglandin-Endoperoxide Synthases
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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