Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in β
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 03 2022
23 03 2022
Historique:
received:
20
11
2021
accepted:
08
03
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Reactivating of fetal hemoglobin (HbF; α2γ2) can ameliorate the severity of β-thalassemia disease by compensating for adult hemoglobin deficiency in patients. Previously, microarray analysis revealed that zinc finger protein (ZNF)802 (also known as Juxta-posed with another zinc finger gene-1 (JAZF1)) was upregulated in human erythroblasts derived from adult peripheral blood compared with fetal liver-derived cells, implying a potential role as a HbF repressor. However, deficiency in ZNF802 induced by lentiviral shRNA in β
Identifiants
pubmed: 35322124
doi: 10.1038/s41598-022-08920-8
pii: 10.1038/s41598-022-08920-8
pmc: PMC8943019
doi:
Substances chimiques
Co-Repressor Proteins
0
DNA-Binding Proteins
0
JAZF1 protein, human
0
Transcription Factors
0
gamma-Globins
0
Fetal Hemoglobin
9034-63-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4952Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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