NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population.
Cardiac markers
Epidemiology studies
Heart failure
Reference intervals
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
16
02
2022
received:
22
10
2021
accepted:
07
03
2022
pubmed:
25
3
2022
medline:
6
5
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver-operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT-proBNP and hs-troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40-49 years. Sex-specific and age-specific cut-offs for hs-troponin T (99th percentiles) and NT-proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex-specific and age-specific cut-offs for NT-proBNP had higher specificity for subclinical HF compared with the previously established single cut-off 125 pg/mL. Age-specific cut-off for hs-troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut-off 14 ng/L. These cut-offs had high specificity, but low sensitivity, that makes hs-troponin T and NT-proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. N-terminal pro-brain natriuretic peptide and hs-troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity.
Identifiants
pubmed: 35322586
doi: 10.1002/ehf2.13906
pmc: PMC9065856
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
Troponin T
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1954-1962Informations de copyright
© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
Rev Esp Cardiol (Engl Ed). 2012 Jul;65(7):613-9
pubmed: 22541282
PLoS One. 2015 Aug 05;10(8):e0134376
pubmed: 26244664
Clin Chem. 2010 Feb;56(2):254-61
pubmed: 19959623
J Card Fail. 2005 Jun;11(5 Suppl):S15-20
pubmed: 15948095
J Am Soc Echocardiogr. 2018 Nov;31(11):1209-1211
pubmed: 30269910
Eur J Heart Fail. 2013 Oct;15(10):1102-12
pubmed: 23787717
Clin Chem. 2015 Dec;61(12):1446-52
pubmed: 26510957
Int J Cardiol. 2016 Apr 15;209:26-33
pubmed: 26878470
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Clin Chem. 2019 Oct;65(10):1221-1227
pubmed: 31387884
JAMA. 2003 Jan 8;289(2):194-202
pubmed: 12517230
J Card Fail. 2009 Jun;15(5):377-84
pubmed: 19477397
Br J Gen Pract. 2006 May;56(526):327-33
pubmed: 16638247
Clin Chem Lab Med. 2013 May;51(5):1125-33
pubmed: 23183754
JAMA Intern Med. 2013 Sep 23;173(17):1592-8
pubmed: 23877591
Eur J Heart Fail. 2016 Nov;18(11):1342-1350
pubmed: 27813304
Am J Med. 2015 Mar;128(3):276-82
pubmed: 25447612
J Card Fail. 2016 Jan;22(1):17-23
pubmed: 26093333
Int J Cardiol. 2010 Apr 30;140(3):336-43
pubmed: 19147239
Arch Gerontol Geriatr. 2016 Jul-Aug;65:111-5
pubmed: 27017416
Arch Intern Med. 2011 Jun 27;171(12):1082-7
pubmed: 21709107
Clin Chim Acta. 2011 Apr 11;412(9-10):748-54
pubmed: 21219893
N Engl J Med. 2004 Feb 12;350(7):655-63
pubmed: 14960742
Arch Gerontol Geriatr. 2015 Sep-Oct;61(2):296-300
pubmed: 25991044
Heart. 2007 Sep;93(9):1137-46
pubmed: 17699180
Eur J Heart Fail. 2005 Jun;7(4):537-41
pubmed: 15921792
Eur Heart J. 2012 Jul;33(14):1787-847
pubmed: 22611136
Int J Cardiol. 2013 Aug 20;167(4):1423-9
pubmed: 22560907
ESC Heart Fail. 2022 Jun;9(3):1954-1962
pubmed: 35322586
N Engl J Med. 2006 Jul 20;355(3):251-9
pubmed: 16855265
Circ Heart Fail. 2012 May 1;5(3):303-6
pubmed: 22589364