Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species
Aurantiochytrium
bioinformatic analysis
marine thraustochytrids
squalene
squalene synthase
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
28 Feb 2022
28 Feb 2022
Historique:
received:
04
01
2022
revised:
09
02
2022
accepted:
25
02
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
1
4
2022
Statut:
epublish
Résumé
The marine microorganisms thraustochytrids have been explored for their potential in the production of various bioactive compounds, such as DHA, carotenoids, and squalene. Squalene is a secondary metabolite of the triterpenoid class and is known for its importance in various industrial applications. The bioinformatic analysis for squalene synthase (SQS) gene (the first key enzyme in the tri-terpenoid synthesis pathway), that is prevailing among thraustochytrids, is poorly investigated. In-silico studies combining sequence alignments and bioinformatic tools helped in the preliminary characterization of squalene synthases found in
Identifiants
pubmed: 35323479
pii: md20030180
doi: 10.3390/md20030180
pmc: PMC8955342
pii:
doi:
Substances chimiques
Ligands
0
Farnesyl-Diphosphate Farnesyltransferase
EC 2.5.1.21
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swedish Research Council
ID : 2020-01028
Organisme : Kempe Foundation
ID : JCK-2115 L3
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