Foundations of circadian medicine.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
21
4
2022
Statut:
epublish
Résumé
The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies. The emerging field of circadian medicine aims to exploit the mechanisms of circadian physiology and clock-disease interaction for clinical diagnosis, treatment, and prevention. In this Essay, we outline the principle approaches of circadian medicine, highlight the development of the field in selected areas, and point out open questions and challenges. Circadian medicine has unambiguous health benefits over standard care but is rarely utilized. It is time for clock biology to become an integrated part of translational research.
Identifiants
pubmed: 35324893
doi: 10.1371/journal.pbio.3001567
pii: PBIOLOGY-D-21-03167
pmc: PMC8946668
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3001567Déclaration de conflit d'intérêts
I have read the journal’s policy and the authors of this manuscript have the following competing interests: AK’s institution has issued patents (PCT/EP2018/066771) and is preparing patents related to biomarkers for detecting the clock. This intellectual property has been licensed by BodyClock GmbH, in which AK is a shareholder. AK receives editor’s honoraria from Springer Verlag and Georg Thieme Verlag. AK is a paid consultant to Circadian Therapeutics, and Stanford University. AK is member of the Editorial Board of PLoS Biology. In addition, he and his research program have received financial, material and travel support from a range of federal, industrial, legal and philanthropic organizations in the past and present. CS reports grants from Deutsche Forschungsgemeinschaft / German Research Society, grants from Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) /German Aerospace Center, grants from Einstein Stiftung Berlin/ Einstein Foundation Berlin, grants from Gemeinsamer Bundesausschuss / Federal Joint Committee (G-BA), grants from Inneruniversitäre Forschungsförderung / Inner University Grants, grants from Projektträger im DLR / Project Management Agency, grants from Stifterverband/Non-Profit Society Promoting Science and Education, grants from European Society of Anaesthesiology and Intensive Care, grants from Baxter Deutschland GmbH, grants from Cytosorbents Europe GmbH, grants from Edwards Lifesciences Germany GmbH, grants from Fresenius Medical Care, grants from Grünenthal GmbH, grants from Masimo Europe Ltd., grants from Pfizer Pharma PFE GmbH, personal fees from Georg Thieme Verlag, grants from Dr. F. Köhler Chemie GmbH, grants from Sintetica GmbH, grants from Stifterverband für die deutsche Wissenschaft e.V. / Philips grants from Stiftung Charité, grants from AGUETTANT Deutschland GmbH, grants from AbbVie Deutschland GmbH & Co. KG, grants from Amomed Pharma GmbH, grants from InTouch Health, grants from Copra System GmbH, grants from Correvio GmbH, grants from Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., grants from Deutsche Gesellschaft für Anästhesiologie & Intensivmedizin (DGAI, grants from Stifterverband für die deutsche Wissenschaft Þ.V. / Metronic, grants from Philips ElectronicsNederland BV, grants from BMG, grants from BMBF, grants from BMBF, grants from Drägerwerk AG & Co. KGaA, outside the submitted work; In addition, CS has a patent 10 2014 215 211.9 licensed, a patent 10 2018 114 364.8 licensed, a patent 10 2018 110 275.5 licensed, a patent 50 2015 010 534.8 licensed, a patent 50 2015 010 347.7 licensed, and a patent 10 2014 215 212.7 licensed.
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