The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale.

Rhodobacter sphaeroides / metabolism Bacterial Proteins / chemistry Circadian Rhythm / physiology Protein Folding Protein Conformation Circadian Rhythm Signaling Peptides and Proteins / metabolism Models, Molecular Magnetic Resonance Spectroscopy
circadian rhythm metamorphic protein relaxation dispersion NMR

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 Nov 2024
Historique:
medline: 31 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: ppublish

Résumé

How can a single protein domain encode a conformational landscape with multiple stably folded states, and how do those states interconvert? Here, we use real-time and relaxation-dispersion NMR to characterize the conformational landscape of the circadian rhythm protein KaiB from

Identifiants

DOI: 10.1073/pnas.2412293121 PMID: 39475637
pubmed: 39475637
doi: 10.1073/pnas.2412293121
doi:

Substances chimiques

Bacterial Proteins 0
Circadian Rhythm Signaling Peptides and Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2412293121

Déclaration de conflit d'intérêts

Competing interests statement:D.K. is a co-founder of Relay Therapeutics and MOMA Therapeutics. The remaining authors declare no competing interests.

Auteurs

Hannah K Wayment-Steele (HK)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0003-4949-2010

Renee Otten (R)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0001-7342-6131

Warintra Pitsawong (W)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0001-5438-1783

Adedolapo M Ojoawo (AM)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0003-3961-8935

Andrew Glaser (A)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.

Logan A Calderone (LA)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0002-0960-3831

Dorothee Kern (D)

Department of Biochemistry, Brandeis University, Waltham, MA 02453.
HHMI, Waltham, MA 02453.
ORCID: 0000-0002-7631-8328

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Classifications MeSH

questionsmedicales.fr › Bactéries › Proteobacteria › Alphaproteobacteria › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides › The conformational landscape of fold-switcher...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › The conformational landscape of fold-switcher...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › The conformational landscape of fold-switcher...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › The conformational landscape of fold-switcher...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › The conformational landscape of fold-switcher...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines et peptides de signalisation du rythme circadien › The conformational landscape of fold-switcher...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › The conformational landscape of fold-switcher...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › The conformational landscape of fold-switcher...