Tissue-resident FOLR2
CD8(+) T lymphocytes
FOLR2
TREM2
breast cancer
single-cell RNA sequencing
tissue-resident macrophages
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
31 03 2022
31 03 2022
Historique:
received:
16
11
2020
revised:
08
10
2021
accepted:
15
02
2022
pubmed:
25
3
2022
medline:
19
4
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2
Identifiants
pubmed: 35325594
pii: S0092-8674(22)00201-X
doi: 10.1016/j.cell.2022.02.021
pii:
doi:
Substances chimiques
FOLR2 protein, human
0
Folate Receptor 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1189-1207.e25Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A19258
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors J.H., R.N.R., E.P., and P.G. and their institutions have filed a patent related to this work.