A hyperbranched polyglycerol-functionalized polymer polar stationary phase.

Glycerol Hydrophobic and Hydrophilic Interactions Polymerization Polymers / chemistry
Hydrophilic interaction liquid chromatography Hyperbranched polyglycerol Polymer Stationary phase Surface-initiated ring-opening polymerization

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
10 May 2022
Historique:
received: 19 01 2022
revised: 25 02 2022
accepted: 07 03 2022
pubmed: 25 3 2022
medline: 14 4 2022
entrez: 24 3 2022
Statut: ppublish

Résumé

A polymer polar stationary phase functionalized with hyperbranched polyglycerol for hydrophilic interaction chromatography (HILIC) is described. It is prepared via surface-initiated ring-opening polymerization of hyperbranched polyglycerol onto hydrolzed poly(glycidyl methacrylate-divinylbenzene) microspheres. The capacity of the functional groups can be maniputed by repeating hyperbranch layers. The phase showed typical HILIC character with good separation performance towards tested polar analytes. It also exhibited wider pH tolerance range (e.g. at least 2 to 12) and as well negligible bleed level under gradient elution mode (even to 50% fraction of water).

Identifiants

DOI: 10.1016/j.chroma.2022.462946 PMID: 35325650
pubmed: 35325650
pii: S0021-9673(22)00144-3
doi: 10.1016/j.chroma.2022.462946
pii:
doi:

Substances chimiques

Polymers 0
polyglycerol 25618-55-7
Glycerol PDC6A3C0OX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

462946

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing financial interest.

Auteurs

Huiliang Geng (H)

Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China.

Zihan Wang (Z)

Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China.

Feifang Zhang (F)

Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China. Electronic address: zhangff@ecust.edu.cn.

Zongying Li (Z)

Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China.

Bingcheng Yang (B)

Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China. Electronic address: bcyang@ecust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyols › Dérivés du glycérol › Glycérol › A hyperbranched polyglycerol-functionalized...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › A hyperbranched polyglycerol-functionalized...
questionsmedicales.fr › Phénomènes chimiques › Polymérisation › A hyperbranched polyglycerol-functionalized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › A hyperbranched polyglycerol-functionalized...