Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology.
Frontotemporal lobar degeneration
Magnetic resonance imaging
Percent area occupied
Sporadic
TDP-43
Tau
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
22
06
2021
revised:
14
02
2022
accepted:
16
02
2022
pubmed:
25
3
2022
medline:
26
4
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Frontotemporal lobar degeneration (FTLD) includes clinically similar FTLD-tau or FTLD-TDP proteinopathies which lack in vivo markers for accurate antemortem diagnosis. To identify early distinguishing sites of cortical atrophy between groups, we retrospectively analyzed in vivo volumetric MRI from 42 FTLD-Tau and 21 FTLD-TDP patients and validated these findings with postmortem measures of pathological burden. Our frequency-based staging model revealed distinct loci of maximal early cortical atrophy in each group, including dorsolateral and medial frontal regions in FTLD-Tau and ventral frontal and anterior temporal regions in FTLD-TDP. Sørenson-Dice calculations between proteinopathy groups showed little overlap of phases. Conversely, within-group subtypes showed good overlap between 3R- and 4R-tauopathies, and between TDP-43 Types A and C for early regions with subtle divergence between subtypes in subsequent phases of atrophy. Postmortem validation found an association of imaging phases with pathologic burden within FTLD-tau (F
Identifiants
pubmed: 35325815
pii: S0197-4580(22)00027-6
doi: 10.1016/j.neurobiolaging.2022.02.007
pmc: PMC9241163
mid: NIHMS1793212
pii:
doi:
Substances chimiques
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-107Subventions
Organisme : NIA NIH HHS
ID : U01 AG052943
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG066597
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054519
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG061277
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109260
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Alzheimers Dement. 2017 Aug;13(8):858-869
pubmed: 28264768
Acta Neuropathol. 2015 Apr;129(4):469-91
pubmed: 25549971
Acta Neuropathol. 2014 Mar;127(3):423-439
pubmed: 24407427
Ann Neurol. 2016 Feb;79(2):272-87
pubmed: 26583316
Biometrics. 1982 Dec;38(4):963-74
pubmed: 7168798
PLoS Biol. 2008 Jul 1;6(7):e159
pubmed: 18597554
Brain. 2010 Jul;133(Pt 7):2045-57
pubmed: 20584946
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Mar;15(1-2):9-14
pubmed: 23781974
Arch Neurol. 2008 Feb;65(2):249-55
pubmed: 18268196
Alzheimers Dement. 2014 Jul;10(4):477-484.e1
pubmed: 23978324
Neuropathol Appl Neurobiol. 2019 Feb;45(1):19-40
pubmed: 30357887
Brain. 2018 Jan 1;141(1):288-301
pubmed: 29228211
Nat Rev Neurol. 2010 Feb;6(2):88-97
pubmed: 20139998
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Ann Neurol. 2013 Jul;74(1):20-38
pubmed: 23686809
Nat Rev Neurosci. 2015 Feb;16(2):109-20
pubmed: 25588378
Acta Neuropathol. 2020 Apr;139(4):717-734
pubmed: 31950334
Acta Neuropathol. 2015 Feb;129(2):221-37
pubmed: 25534024
Neuron. 2019 Dec 4;104(5):856-868.e5
pubmed: 31623919
Acta Neuropathol. 2019 Nov;138(5):705-727
pubmed: 31203391
Neuroimage. 2014 Oct 1;99:166-79
pubmed: 24879923
Nat Rev Neurol. 2012 Jan 31;8(3):131-42
pubmed: 22290573
Acta Neuropathol Commun. 2021 Feb 23;9(1):30
pubmed: 33622418
Front Neurosci. 2019 Jul 03;13:682
pubmed: 31333403
Ann Neurol. 2017 Mar;81(3):430-443
pubmed: 28133816
Neurology. 2002 Apr 23;58(8):1161-8
pubmed: 11971081
Front Neuroinform. 2014 Apr 28;8:44
pubmed: 24817849
Acta Neuropathol. 2019 Jan;137(1):27-46
pubmed: 30511086
Acta Neuropathol. 1972;21(3):224-31
pubmed: 5056008
J Neuropathol Exp Neurol. 1994 Jan;53(1):37-42
pubmed: 8301318
Nat Med. 2014 Feb;20(2):130-8
pubmed: 24504409
Neurobiol Aging. 2008 Feb;29(2):280-9
pubmed: 17097770
J Neurosci. 2012 Nov 14;32(46):16265-73
pubmed: 23152610
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
Hum Brain Mapp. 2012 Jul;33(7):1526-35
pubmed: 21618662
Neuroimage Clin. 2016 May 30;11:802-812
pubmed: 28050342
Neuroimage. 2010 Dec;53(4):1208-24
pubmed: 20600984
Cereb Cortex. 2012 Feb;22(2):251-9
pubmed: 21653702
J Mol Neurosci. 2011 Nov;45(3):379-83
pubmed: 21552993
J Comp Neurol. 2013 Dec 15;521(18):4339-55
pubmed: 23881776
Acta Neuropathol. 2019 Jan;137(1):1-26
pubmed: 30368547
Brain. 2007 Apr;130(Pt 4):1148-58
pubmed: 17347250
JAMA Neurol. 2013 Nov;70(11):1411-7
pubmed: 24081456
Acta Neuropathol. 2010 Jan;119(1):1-4
pubmed: 19924424
Ann Clin Transl Neurol. 2020 Dec;7(12):2342-2355
pubmed: 33108692
Neuropathology. 2014 Aug;34(4):386-91
pubmed: 24444359
Acta Neuropathol. 2017 Jul;134(1):65-78
pubmed: 28130640
Brain. 2017 Dec 1;140(12):3329-3345
pubmed: 29053860
Acta Neuropathol. 1992;84(3):265-72
pubmed: 1384266
Neurosci Bull. 2019 Apr;35(2):229-243
pubmed: 30790214
Brain. 2009 Nov;132(Pt 11):2932-46
pubmed: 19762452
Nature. 2020 Apr;580(7802):283-287
pubmed: 32050258
Alzheimers Dement. 2012 Jan;8(1):1-13
pubmed: 22265587
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
J Neurosci. 2017 Nov 22;37(47):11406-11423
pubmed: 29054878
J Neurochem. 2016 Aug;138 Suppl 1:54-70
pubmed: 27306735
J Histochem Cytochem. 2016 Jan;64(1):54-66
pubmed: 26538548
Brain. 2014 Jun;137(Pt 6):1733-40
pubmed: 24736303
Neurology. 2020 Dec 15;95(24):e3190-e3202
pubmed: 32989107
Ann Neurol. 2019 May;85(5):630-643
pubmed: 30851133
Neurobiol Aging. 2018 Mar;63:75-87
pubmed: 29223682
Science. 2006 Oct 6;314(5796):130-3
pubmed: 17023659
Acta Neuropathol. 2009 Feb;117(2):137-49
pubmed: 19125255
Acta Neuropathol. 2020 Aug;140(2):99-119
pubmed: 32383020