Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation.
COX2/PGE2
IL-10
histone modification
inflammation
obesity
palmitic acid
periodontitis
tooth movement
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
10 03 2022
10 03 2022
Historique:
received:
19
01
2022
revised:
08
03
2022
accepted:
09
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
14
4
2022
Statut:
epublish
Résumé
The interrelationships between periodontal disease, obesity-related hyperlipidemia and mechanical forces and their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex. The PdL serves as a connective tissue between teeth and alveolar bone and is involved in pathogen defense and the inflammatory responses to mechanical stimuli occurring during tooth movement. Altered inflammatory signaling could promote root resorption and tooth loss. Hyperinflammatory COX2/PGE2 signaling was reported for human PdL fibroblasts (HPdLFs) concomitantly stressed with
Identifiants
pubmed: 35326406
pii: cells11060955
doi: 10.3390/cells11060955
pmc: PMC8946768
pii:
doi:
Substances chimiques
Histones
0
Palmitates
0
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Interdisciplinary Center of Clinical Research of the Medical Faculty Jena
ID : MSP-08
Organisme : Program for the Support of Third-Party Funding for Young Scientists 2018 Program Line B (Basic) of the Friedrich-Schiller University Jena
ID : DRM/2018-10
Références
Cell Biochem Biophys. 2011 Mar;59(2):89-97
pubmed: 20809180
Nutr Hosp. 2012 Jul-Aug;27(4):978-90
pubmed: 23165533
J Dent Res. 2017 May;96(5):547-554
pubmed: 28113000
Endocrinology. 2015 Nov;156(11):4081-93
pubmed: 26327577
Inflamm Res. 2019 Nov;68(11):915-932
pubmed: 31363792
Diabetologia. 1976 Dec;12(6):563-71
pubmed: 187517
Biochim Biophys Acta. 2014 Aug;1839(8):627-43
pubmed: 24631868
Cancer Biol Ther. 2014;15(12):1677-87
pubmed: 25535899
J Med Chem. 2016 Feb 25;59(4):1299-307
pubmed: 26796965
J Cell Biochem. 2016 Jun;117(6):1384-95
pubmed: 27043246
J Bone Miner Res. 2002 Feb;17(2):210-20
pubmed: 11811551
Mol Cell Endocrinol. 2016 Feb 15;422:233-242
pubmed: 26747726
Database (Oxford). 2021 Apr 7;2021:
pubmed: 33826699
FASEB J. 2009 Dec;23(12):4317-26
pubmed: 19671668
Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):149-59
pubmed: 16829065
Arch Oral Biol. 2013 May;58(5):511-22
pubmed: 23116693
J Orthod. 2019 Dec;46(4):323-334
pubmed: 31522589
J Bone Miner Metab. 2012 Jul;30(4):419-25
pubmed: 22246084
J Periodontal Res. 2011 Dec;46(6):697-703
pubmed: 21745207
Br Dent J. 2014 Oct;217(8):405-9
pubmed: 25342346
J Clin Periodontol. 1996 Aug;23(8):743-9
pubmed: 8877660
Sci Rep. 2020 Sep 24;10(1):15706
pubmed: 32973207
Prostaglandins Leukot Essent Fatty Acids. 1989 Mar;35(3):157-64
pubmed: 2710799
Eur J Orthod. 2003 Apr;25(2):199-204
pubmed: 12737218
Nat Rev Genet. 2012 Apr 03;13(5):343-57
pubmed: 22473383
Epigenetics. 2018;13(5):536-556
pubmed: 29912614
J Immunol. 2001 Feb 15;166(4):2674-80
pubmed: 11160331
Epigenetics. 2020 Nov;15(11):1259-1274
pubmed: 32441560
Carcinogenesis. 2010 Mar;31(3):489-95
pubmed: 19969553
Toxicol Lett. 2011 Oct 30;206(3):268-75
pubmed: 21878375
J Periodontol. 2008 Aug;79(8 Suppl):1577-84
pubmed: 18673013
FASEB J. 2014 Jul;28(7):3183-96
pubmed: 24652950
Plant Methods. 2007 Sep 24;3:11
pubmed: 17892552
J Orofac Orthop. 2014 May;75(3):191-202
pubmed: 24825831
Diabetes. 1957 Nov-Dec;6(6):475-9
pubmed: 13473641
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):149-54
pubmed: 20206486
Diagnostics (Basel). 2016 Dec 22;7(1):
pubmed: 28025506
Carcinogenesis. 2009 Mar;30(3):377-86
pubmed: 19136477
J Clin Invest. 1985 Aug;76(2):637-44
pubmed: 3897287
Front Pharmacol. 2019 Jan 21;9:1554
pubmed: 30719005
Immunity. 2014 Jun 19;40(6):865-79
pubmed: 24856900
Nature. 2011 Jan 20;469(7330):343-9
pubmed: 21248841
Front Immunol. 2021 Nov 19;12:781378
pubmed: 34868054
Int J Mol Sci. 2021 Dec 19;22(24):
pubmed: 34948405
Obesity (Silver Spring). 2008 May;16(5):938-44
pubmed: 18356844
Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E35-44
pubmed: 25944880
Prostaglandins Leukot Essent Fatty Acids. 1991 Jul;43(3):197-201
pubmed: 1871184
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov;1866(11):159019
pubmed: 34332076
Nature. 2021 Nov;599(7885):485-490
pubmed: 34759321
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20466-71
pubmed: 18077329
J Virol. 2014 Apr;88(8):4466-79
pubmed: 24501407
Curr Oral Health Rep. 2017;4(4):286-293
pubmed: 29201597
Blood. 2014 Jul 31;124(5):737-49
pubmed: 24951427
J Clin Invest. 1991 Apr;87(4):1431-41
pubmed: 2010553
Am J Orthod Dentofacial Orthop. 2010 Apr;137(4):462-76; discussion 12A
pubmed: 20362905
Biomolecules. 2021 Jun 23;11(7):
pubmed: 34201602
Inflamm Res. 2021 Jan;70(1):29-49
pubmed: 33231704
Epigenetics Chromatin. 2020 Oct 31;13(1):47
pubmed: 33129354
ACS Chem Biol. 2013;8(6):1324-34
pubmed: 23614352
Front Genet. 2014 Sep 24;5:311
pubmed: 25309573
Sci Rep. 2017 Nov 7;7(1):14751
pubmed: 29116140
Eur J Histochem. 2017 Aug 25;61(3):2826
pubmed: 29046054
Nat Commun. 2021 Oct 27;12(1):6212
pubmed: 34707105
Genet Epigenet. 2014 May 27;6:9-19
pubmed: 25512710
BMC Genomics. 2009 Aug 07;10:365
pubmed: 19660143
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):234-245
pubmed: 27845246
Nat Cell Biol. 2016 Aug;18(8):864-75
pubmed: 27398909
Oncotarget. 2016 Sep 13;7(37):59360-59376
pubmed: 27449082
Mediators Inflamm. 2013;2013:530429
pubmed: 24078775
Mol Cell Biol. 2009 Aug;29(15):4325-39
pubmed: 19487460
Jpn Dent Sci Rev. 2017 Nov;53(4):134-140
pubmed: 29201258
Clin Oral Investig. 2020 Jul;24(7):2497-2511
pubmed: 31728735
Am J Orthod Dentofacial Orthop. 1991 Mar;99(3):226-40
pubmed: 1705387
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nature. 2007 May 24;447(7143):396-8
pubmed: 17522671
Aust Dent J. 2017 Mar;62 Suppl 1:86-96
pubmed: 27868202
Mol Nutr Food Res. 2018 Oct;62(20):e1800322
pubmed: 30102465
Endocrinology. 2010 Feb;151(2):537-48
pubmed: 20022932
Int J Obes. 1989;13(5):603-12
pubmed: 2583914
J Cell Mol Med. 2021 Jan;25(2):892-904
pubmed: 33289330
Int J Mol Sci. 2021 Feb 27;22(5):
pubmed: 33673606
Cell Rep. 2016 Nov 1;17(6):1463-1472
pubmed: 27806287
Eur J Pharmacol. 2016 Aug 15;785:207-214
pubmed: 27083551
Eur J Dent. 2021 Oct;15(4):727-732
pubmed: 34331301
Cell Death Dis. 2020 Sep 15;11(9):757
pubmed: 32934212
J Periodontal Res. 2011 Apr;46(2):153-7
pubmed: 21118418
Ann Anat. 2017 Mar;210:32-43
pubmed: 27838559
Angle Orthod. 2017 Sep;87(5):739-744
pubmed: 28471265
Clin Epigenetics. 2020 Nov 30;12(1):186
pubmed: 33256844
Dental Press J Orthod. 2017 May-Jun;22(3):21-25
pubmed: 28746484
Eur J Immunol. 2020 Dec;50(12):1929-1940
pubmed: 32662520
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):84-91
pubmed: 17082484
Cell Rep. 2019 Nov 19;29(8):2321-2337.e7
pubmed: 31747604
Int J Mol Sci. 2021 Jun 04;22(11):
pubmed: 34199865