The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes.
3T3 embryonic cells
FRET nanosensor
G-protein-coupled receptors
GPR27
aerobic glycolysis
agonists
astrocytes
cytosolic L-lactate
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 03 2022
16 03 2022
Historique:
received:
25
01
2022
revised:
03
03
2022
accepted:
10
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
13
4
2022
Statut:
epublish
Résumé
G-protein-coupled receptors (GPCRs) represent a family with over 800 members in humans, and one-third of these are targets for approved drugs. A large number of GPCRs have unknown physiologic roles. Here, we investigated GPR27, an orphan GPCR belonging to the family of super conserved receptor expressed in the brain, with unknown functions. Cytosolic levels of L-lactate ([lactate]
Identifiants
pubmed: 35326460
pii: cells11061009
doi: 10.3390/cells11061009
pmc: PMC8947442
pii:
doi:
Substances chimiques
Gpr27 protein, mouse
0
Receptors, G-Protein-Coupled
0
Lactic Acid
33X04XA5AT
Glycogen
9005-79-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Slovenian Research Agency
ID : J3-6790, J3-9266, J3-2523
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