Vogt-Koyanagi-Harada Disease Exacerbation Associated with COVID-19 Vaccine.
COVID-19 vaccine
VKH disease
uveitis
vaccine-associated autoimmunity
vitiligo
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 03 2022
16 03 2022
Historique:
received:
31
01
2022
revised:
08
03
2022
accepted:
11
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
We describe a case of Vogt-Koyanagi-Harada (VKH) disease exacerbation after COVID-19 vaccination. A 46-year-old woman presented with a bilateral granulomatous uveitis 2 days after the first dose of COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech), and was diagnosed with a complete Vogt-Koyanagi-Harada (VKH) disease 4 days after receiving the second dose of the vaccine. Three weeks before the first dose, she had been consulted for blurred vision and mild headaches. The case resolved with high dose intravenous corticosteroids, followed by oral prednisone. The close temporal relationship between the COVID-19 vaccine doses and the worsening of VKH symptoms strongly suggests COVID-19 vaccination as the trigger of its exacerbation.
Identifiants
pubmed: 35326462
pii: cells11061012
doi: 10.3390/cells11061012
pmc: PMC8947156
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Vaccines, Synthetic
0
mRNA Vaccines
0
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : RETICS RD16/0008/0003
Organisme : Xunta de Galicia
ID : ED431G 2019/02
Organisme : Ministry of Economy, Industry and Competitiveness
ID : RTI2018-101840-B-I00
Organisme : European Union
ID : EURONANOMED2019-050-ENAMEP
Références
Ophthalmol Ther. 2021 Jun;10(2):201-209
pubmed: 33675508
Autoimmun Rev. 2021 Apr;20(4):102792
pubmed: 33610751
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1212-1215
pubmed: 34505819
MMWR Morb Mortal Wkly Rep. 2021 Jul 09;70(27):977-982
pubmed: 34237049
Clin Immunol. 2021 Mar;224:108665
pubmed: 33429060
Nat Rev Immunol. 2020 Oct;20(10):615-632
pubmed: 32887954
Vaccines (Basel). 2021 Apr 29;9(5):
pubmed: 33946748
Ann Rheum Dis. 2021 Oct;80(10):1306-1311
pubmed: 33762264
Clin Infect Dis. 2022 Mar 1;74(4):715-718
pubmed: 34015087
Int J Retina Vitreous. 2021 Aug 30;7(1):49
pubmed: 34462013
J Ophthalmic Inflamm Infect. 2021 Jul 5;11(1):21
pubmed: 34224024
Am J Ophthalmol. 2001 May;131(5):647-52
pubmed: 11336942
Ann Rheum Dis. 2021 Mar 23;:
pubmed: 33757968
Ann Rheum Dis. 2021 Mar 19;:
pubmed: 33741555
Surv Ophthalmol. 2017 Jan - Feb;62(1):1-25
pubmed: 27241814