Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams.
fetal programming
gestational diabetes
multiparity
obesity
placental insulin receptor
type 2 diabetes
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
received:
03
02
2022
revised:
25
02
2022
accepted:
27
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
In pregnancies complicated by maternal obesity and gestational diabetes mellitus, there is strong evidence to suggest that the insulin signaling pathway in the placenta may be impaired. This may have potential effects on the programming of the metabolic health in the offspring; however, a direct link between the placental insulin signaling pathway and the offspring health remains unknown. Here, we aimed to understand whether specific placental loss of the insulin receptor (InsR) has a lasting effect on the offspring health in mice. Obesity and glucose homeostasis were assessed in the adult mouse offspring on a normal chow diet (NCD) followed by a high-fat diet (HFD) challenge. Compared to their littermate controls, InsR KO
Identifiants
pubmed: 35327377
pii: biomedicines10030575
doi: 10.3390/biomedicines10030575
pmc: PMC8945682
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : R01DK115720, R21HD100840
Pays : United States
Références
Curr Diab Rep. 2016 Jan;16(1):7
pubmed: 26742932
J Obes. 2019 Feb 10;2019:2419263
pubmed: 30881701
Development. 2020 Apr 12;147(7):
pubmed: 32165492
J Clin Endocrinol Metab. 2015 Jan;100(1):159-65
pubmed: 25365315
JCI Insight. 2021 Jul 8;6(13):
pubmed: 34032632
Int J Mol Sci. 2021 Jun 28;22(13):
pubmed: 34203166
Front Physiol. 2016 Jan 29;7:12
pubmed: 26858656
Biol Sex Differ. 2013 Mar 21;4(1):5
pubmed: 23514128
Am J Public Health. 2009 Feb;99(2):294-9
pubmed: 19059856
Ann Nutr Metab. 2016;69(3-4):171-180
pubmed: 27855382
J Taibah Univ Med Sci. 2017 Feb 22;12(4):338-342
pubmed: 31435260
J Biol Chem. 2010 May 28;285(22):17235-45
pubmed: 20360006
Pak J Biol Sci. 2017;20(1):42-46
pubmed: 29023014
Annu Rev Physiol. 2003;65:313-32
pubmed: 12471165
Dev Biol. 1997 Sep 1;189(1):33-48
pubmed: 9281335
Eur J Endocrinol. 2009 Apr;160(4):567-78
pubmed: 19179458
Int J Obes (Lond). 2020 Oct;44(10):1981-2000
pubmed: 32494038
Int J Mol Sci. 2020 Jul 15;21(14):
pubmed: 32679915
BMJ. 2017 Feb 8;356:j1
pubmed: 28179267
J Dev Orig Health Dis. 2010 Aug;1(4):208-15
pubmed: 25141869
Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E449-57
pubmed: 22127227
Diabetes. 2018 Nov;67(11):2137-2151
pubmed: 30348820
Genesis. 2007 Mar;45(3):129-34
pubmed: 17299749
Diabet Med. 2014 Mar;31(3):273-81
pubmed: 24341419
J Anat. 2009 Jul;215(1):60-8
pubmed: 19467150
Diabetes Care. 2007 Jul;30 Suppl 2:S120-6
pubmed: 17596459
Diabetologia. 1992 Jan;35(1):45-55
pubmed: 1541381
Placenta. 2006 Apr;27 Suppl A:S109-13
pubmed: 16542722
Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R867-R878
pubmed: 30110175
J Womens Health (Larchmt). 2015 Jul;24(7):602-7
pubmed: 26172999
Placenta. 2017 Sep;57:26-32
pubmed: 28864016
Curr Diab Rep. 2019 Nov 21;19(12):143
pubmed: 31754898
Biol Psychiatry. 2017 Jul 15;82(2):127-138
pubmed: 28168960
Clin Obstet Gynecol. 2013 Sep;56(3):591-601
pubmed: 23703224
Pediatr Res. 2011 Feb;69(2):175-80
pubmed: 21076366
BJOG. 2006 Oct;113(10):1126-33
pubmed: 16827826
Clin Obstet Gynecol. 2007 Dec;50(4):972-9
pubmed: 17982340
Lancet Diabetes Endocrinol. 2017 Jan;5(1):53-64
pubmed: 27743978
Am J Physiol Regul Integr Comp Physiol. 2020 Oct 1;319(4):R485-R496
pubmed: 32877242
Nat Commun. 2017 Mar 27;8:14892
pubmed: 28345670
Am J Obstet Gynecol. 2009 Aug;201(2):177.e1-9
pubmed: 19560114
Ann Nutr Metab. 2017;70(1):16-25
pubmed: 28110332
Pak J Med Sci. 2013 May;29(3):843-6
pubmed: 24353640
Nestle Nutr Inst Workshop Ser. 2016;85:59-69
pubmed: 27088333
J Mol Endocrinol. 2019 Feb 1;62(2):R155-R165
pubmed: 30400060
Prev Chronic Dis. 2014 Jun 19;11:E104
pubmed: 24945238
Mol Cell Endocrinol. 2021 Jul 15;532:111319
pubmed: 33989714
Pediatr Res. 2018 Jun;83(6):1087-1089
pubmed: 29584713
Elife. 2019 Jun 26;8:
pubmed: 31241463
Lancet Diabetes Endocrinol. 2016 Dec;4(12):1025-1036
pubmed: 27743975
Prev Chronic Dis. 2017 Oct 19;14:E102
pubmed: 29072986
Endocrinology. 2015 Oct;156(10):3422-34
pubmed: 26241064