Multicenter


Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
16 03 2022
Historique:
received: 25 01 2022
revised: 09 03 2022
accepted: 12 03 2022
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 23 4 2022
Statut: epublish

Résumé

Tau aggregates accumulate in the Alzheimer's disease (AD) brain according to the established Braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. To impact the management of AD patients, an in vivo tool for tau Braak staging is needed. First-generation tau tracers have limited performance in detecting early stages of tau. Therefore, we tested the corresponding capability of the next-generation tau tracer,

Identifiants

pubmed: 35327650
pii: biom12030458
doi: 10.3390/biom12030458
pmc: PMC8946049
pii:
doi:

Substances chimiques

((18)F)PI-2620 0
Fluorine Radioisotopes 0
Pyridines 0
tau Proteins 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Michael Rullmann (M)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.

Matthias Brendel (M)

Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 80336 Munich, Germany.

Matthias L Schroeter (ML)

Clinic for Cognitive Neurology, University of Leipzig, 04103 Leipzig, Germany.
Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

Dorothee Saur (D)

Department of Neurology, University of Leipzig, 04103 Leipzig, Germany.

Johannes Levin (J)

Department of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Neurodegenerative Disorders (DZNE) Munich, 81377 Munich, Germany.

Robert G Perneczky (RG)

Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Neurodegenerative Disorders (DZNE) Munich, 81377 Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 80336 Munich, Germany.
Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London W6 8RP, UK.
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK.

Solveig Tiepolt (S)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.

Marianne Patt (M)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.

Andre Mueller (A)

Life Molecular Imaging GmbH, 13353 Berlin, Germany.

Victor L Villemagne (VL)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Joseph Classen (J)

Department of Neurology, University of Leipzig, 04103 Leipzig, Germany.

Andrew W Stephens (AW)

Life Molecular Imaging GmbH, 13353 Berlin, Germany.

Osama Sabri (O)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.

Henryk Barthel (H)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.

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Classifications MeSH