The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson's Disease.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Mar 2022
Historique:
received: 22 02 2022
revised: 10 03 2022
accepted: 10 03 2022
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 9 4 2022
Statut: epublish

Résumé

Parkinson's disease (PD) is second-most common disabling neurological disorder worldwide, and unfortunately, there is not yet a definitive way to prevent it. Polyphenols have been widely shown protective efficacy against various PD symptoms. However, data on their effect on physio-pathological mechanisms underlying this disease are still lacking. In the present work, we evaluated the activity of a mixture of polyphenols and micronutrients, named A5

Identifiants

pubmed: 35328530
pii: ijms23063110
doi: 10.3390/ijms23063110
pmc: PMC8955775
pii:
doi:

Substances chimiques

Micronutrients 0
Polyphenols 0
Oxidopamine 8HW4YBZ748

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Francesca Pacifici (F)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Chiara Salimei (C)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Donatella Pastore (D)

Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.

Gina Malatesta (G)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.

Camillo Ricordi (C)

Cell Transplant Center, Diabetes Research Institute, School of Medicine, University of Miami Miller, Miami, FL 33136, USA.

Giulia Donadel (G)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Alfonso Bellia (A)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Medical Sciences, Fondazione Policlinico Tor Vergata, 00133 Rome, Italy.

Valentina Rovella (V)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Medical Sciences, Fondazione Policlinico Tor Vergata, 00133 Rome, Italy.

Marco Tafani (M)

Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.

Enrico Garaci (E)

Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.

Manfredi Tesauro (M)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Davide Lauro (D)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Nicola Di Daniele (N)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

David Della-Morte (D)

Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.
Department of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Interdisciplinary Center for Advanced Studies on Lab-on-Chip and Organ-on-Chip Applications (ICLOC), University of Rome Tor Vergata, 00133 Rome, Italy.

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Classifications MeSH