High throughput screening for compounds to the orphan nuclear receptor NR2F6.

Animals High-Throughput Screening Assays Ligands Mice Neoplasms / pathology Orphan Nuclear Receptors Repressor Proteins
Cancer High-throughput screening (HTS) Immuno-oncology drug discovery NR2F6 Nuclear receptor

Journal

SLAS discovery : advancing life sciences R & D
ISSN: 2472-5560
Titre abrégé: SLAS Discov
Pays: United States
ID NLM: 101697563

Informations de publication

Date de publication:
06 2022
Historique:
received: 21 12 2021
revised: 08 03 2022
accepted: 18 03 2022
pubmed: 26 3 2022
medline: 9 6 2022
entrez: 25 3 2022
Statut: ppublish

Résumé

NR2F6 is considered an orphan nuclear receptor since its endogenous ligand has yet to be identified. Recently, NR2F6 has emerged as a novel cancer therapeutic target. NR2F6 has been demonstrated to be upregulated or overexpressed in several cancers. Importantly, Nr2f6

Identifiants

DOI: 10.1016/j.slasd.2022.03.005 PMID: 35331960 PMC: PMC9670014
pubmed: 35331960
pii: S2472-5552(22)12551-7
doi: 10.1016/j.slasd.2022.03.005
pmc: PMC9670014
mid: NIHMS1844169
pii:
doi:

Substances chimiques

Ligands 0
Nr2f6 protein, mouse 0
Orphan Nuclear Receptors 0
Repressor Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

242-248

Subventions

Organisme : NCI NIH HHS
ID : R01 CA225890
Pays : United States
Organisme : NIH HHS
ID : S10 OD025279
Pays : United States
Organisme : NIH HHS
ID : S10 OD026857
Pays : United States
Organisme : NIH HHS
ID : S10 OD030330
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Conflicting Interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Auteurs

Emery Smith (E)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Sean Campbell (S)

Department of Immunology and Microbiology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Adrianna N Wilson (AN)

Department of Immunology and Microbiology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Justin Shumate (J)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Pierre Baillargeon (P)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Louis Scampavia (L)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Theodore M Kamenecka (TM)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Timothy P Spicer (TP)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA.

Laura A Solt (LA)

Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA; Department of Immunology and Microbiology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL, 33458, USA. Electronic address: lsolt@scripps.edu.

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Classifications MeSH

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