Theodore M Kamenecka

Affiliations

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.

Publications (33)

A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors.

Journal of biological methods

Avec: Laszlo Radnai , Rebecca F Stremel , Thomas Vaissiere , Li Lin , Michael Cameron , William H Martin , Gavin Rumbaugh , Theodore M Kamenecka , Patrick R Griffin , Courtney A Miller

Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development.

Biochemical and biophysical research communications

Avec: Mohammed Amir , Sean Campbell , Theodore M Kamenecka , Laura A Solt

MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma.

bioRxiv : the preprint server for biology

Avec: Rajappa Kenchappa , Laszlo Radnai , Erica J Young , Natanael Zarco , Li Lin , Athanassios Dovas , Christian T Meyer , Ashley Haddock , Alice Hall , Peter Canoll , Michael D Cameron , Naveen Kh Nagaiah , Gavin Rumbaugh , Patrick R Griffin , Theodore M Kamenecka , Courtney A Miller , Steven S Rosenfeld

Methamphetamine Learning Induces Persistent and Selective Nonmuscle Myosin II-Dependent Spine Motility in the Basolateral Amygdala.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Erica J Young , Hua Lin , Theodore M Kamenecka , Gavin Rumbaugh , Courtney A Miller

Promoting activity of (α4)

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Avec: Jingyi Wang , Angelo Blasio , Holly L Chapman , Christelle Doebelin , Victor Liaw , Alexander Kuryatov , Simone M Giovanetti , Jon Lindstrom , Li Lin , Michael D Cameron , Theodore M Kamenecka , Matthew B Pomrenze , Robert O Messing

Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways.

ACS chemical biology

Avec: Mi Ra Chang , Anthony Ciesla , Timothy S Strutzenberg , Scott J Novick , Yuanjun He , Ruben D Garcia-Ordonez , Rebecca L Frkic , John B Bruning , Theodore M Kamenecka , Patrick R Griffin

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T

Nature communications

Avec: Ran Wang , Sean Campbell , Mohammed Amir , Sarah A Mosure , Molly A Bassette , Amber Eliason , Mark S Sundrud , Theodore M Kamenecka , Laura A Solt

Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC.

The Journal of biological chemistry

Avec: Jack Norleans , Jingyi Wang , Alexander Kuryatov , Abba Leffler , Christelle Doebelin , Theodore M Kamenecka , Jon Lindstrom

Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.

Aging cell

Avec: Lei Zhang , Jing Zhao , Xiaodong Mu , Sara J McGowan , Luise Angelini , Ryan D O'Kelly , Matthew J Yousefzadeh , Ayumi Sakamoto , Zaira Aversa , Nathan K LeBrasseur , Yousin Suh , Johnny Huard , Theodore M Kamenecka , Laura J Niedernhofer , Paul D Robbins

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.

Journal of medicinal chemistry

Avec: Paola Munoz-Tello , Hua Lin , Pasha Khan , Ian Mitchelle S de Vera , Theodore M Kamenecka , Douglas J Kojetin

Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.

JCI insight

Avec: Davis A Englund , Alyssa M Jolliffe , Gabriel J Hanson , Zaira Aversa , Xu Zhang , Xinyi Jiang , Thomas A White , Lei Zhang , David G Monroe , Paul D Robbins , Laura J Niedernhofer , Theodore M Kamenecka , Sundeep Khosla , Nathan K LeBrasseur

Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization.

Aging

Avec: Chi-Hsiu Liu , Felix Yemanyi , Kiran Bora , Neetu Kushwah , Alexandra K Blomfield , Theodore M Kamenecka , John Paul SanGiovanni , Ye Sun , Laura A Solt , Jing Chen

PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.

ACS chemical biology

Avec: Rebecca L Frkic , Jordan L Pederick , Aimee J Horsfall , Blagojce Jovcevski , Elise E Crame , Wioleta Kowalczyk , Tara L Pukala , Mi Ra Chang , Jie Zheng , Anne-Laure Blayo , Andrew D Abell , Theodore M Kamenecka , Joshua S Harbort , Jeffrey R Harmer , Patrick R Griffin , John B Bruning

Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential.

bioRxiv : the preprint server for biology

Avec: Laszlo Radnai , Erica J Young , Carlos Kikuti , Madalyn Hafenbreidel , Rebecca F Stremel , Li Lin , Katalin Toth , Paolo Pasetto , Xiaomin Jin , Aagam Patel , Michael Conlon , Sherri Briggs , Leïla Heidsieck , H Lee Sweeney , James Sellers , Teresa Krieger-Burke , William H Martin , Jay Sisco , Steven Young , Paul Pearson , Gavin Rumbaugh , Gian Luca Araldi , Steven K Duddy , Michael D Cameron , Matthew Surman , Anne Houdusse , Patrick R Griffin , Theodore M Kamenecka , Courtney A Miller

Habenular TCF7L2 links nicotine addiction to diabetes.

Nature

Avec: Alexander Duncan , Mary P Heyer , Masago Ishikawa , Stephanie P B Caligiuri , Xin-An Liu , Zuxin Chen , Maria Vittoria Micioni Di Bonaventura , Karim S Elayouby , Jessica L Ables , William M Howe , Purva Bali , Clementine Fillinger , Maya Williams , Richard M O'Connor , Zichen Wang , Qun Lu , Theodore M Kamenecka , Avi Ma'ayan , Heidi C O'Neill , Ines Ibanez-Tallon , Aron M Geurts , Paul J Kenny

Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α.

Medicinal chemistry (Shariqah (United Arab Emirates))

Avec: Christelle Doebelin , Yuanjun He , Sean Campbell , Philippe Nuhant , Naresh Kumar , Marcel Koenig , Ruben Garcia-Ordonez , Mi Ra Chang , William R Roush , Li Lin , Susan Kahn , Michael D Cameron , Patrick R Griffin , Laura A Solt , Theodore M Kamenecka

Discovery of Selective Inhibitors for

ACS chemical biology

Avec: Laszlo Radnai , Matthew Surman , Madalyn Hafenbreidel , Erica J Young , Rebecca F Stremel , Li Lin , Bilel Bdiri , Paolo Pasetto , Xiaomin Jin , Mackenzie Geedy , Joni-Rae Partridge , Aagam Patel , Michael Conlon , James R Sellers , Michael D Cameron , Gavin Rumbaugh , Patrick R Griffin , Theodore M Kamenecka , Courtney A Miller

Synthesis and structure activity relationship of the first class of LXR inverse agonists.

Bioorganic chemistry

Avec: Bahaa Elgendy , Kristine Griffett , Lamees Hegazy , Paolo Di Fruscia , Kirby Sample , Emmalie Schoepke , Theodore M Kamenecka , Thomas P Burris

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

Journal of molecular biology

Avec: Timothy S Strutzenberg , Yingmin Zhu , Scott J Novick , Ruben D Garcia-Ordonez , Christelle Doebelin , Yuanjun He , Mi Ra Chang , Theodore M Kamenecka , Dean P Edwards , Patrick R Griffin

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.

Science advances

Avec: Mattia Deluigi , Alexander Klipp , Christoph Klenk , Lisa Merklinger , Stefanie A Eberle , Lena Morstein , Philipp Heine , Peer R E Mittl , Patrick Ernst , Theodore M Kamenecka , Yuanjun He , Santiago Vacca , Pascal Egloff , Annemarie Honegger , Andreas Plückthun

Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.

Nature chemical biology

Avec: Nelson E Bruno , Jerome C Nwachukwu , Sathish Srinivasan , Charles C Nettles , Tina Izard , Zhuang Jin , Jason Nowak , Michael D Cameron , Siddaraju V Boregowda , Donald G Phinney , Olivier Elemento , Xu Liu , Eric A Ortlund , René Houtman , Diana A Stavreva , Gordon L Hager , Theodore M Kamenecka , Douglas J Kojetin , Kendall W Nettles

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2.

Redox biology

Avec: Shuo Huang , Chi-Hsiu Liu , Zhongxiao Wang , Zhongjie Fu , William R Britton , Alexandra K Blomfield , Theodore M Kamenecka , Joshua L Dunaief , Laura A Solt , Jing Chen

Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (

Journal of medicinal chemistry

Avec: Yuanjun He , Di Zhu , Kevin Greenman , Claudia Ruiz , Jinsai Shang , Qun Lu , Douglas J Kojetin , Robert Drakas , Michael D Cameron , Mike Lizarzaburu , Laura A Solt , Theodore M Kamenecka

Structure-Activity Relationship and Biological Investigation of SR18292 (

Journal of medicinal chemistry

Avec: Hua Lin , Kfir Sharabi , Li Lin , Claudia Ruiz , Di Zhu , Michael D Cameron , Scott J Novick , Patrick R Griffin , Pere Puigserver , Theodore M Kamenecka

Quantitative structural assessment of graded receptor agonism.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jinsai Shang , Richard Brust , Patrick R Griffin , Theodore M Kamenecka , Douglas J Kojetin

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists.

eLife

Avec: Timothy S Strutzenberg , Ruben D Garcia-Ordonez , Scott J Novick , HaJeung Park , Mi Ra Chang , Christelle Doebellin , Yuanjun He , Rémi Patouret , Theodore M Kamenecka , Patrick R Griffin

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Christina Chang , Chin-San Loo , Xuan Zhao , Laura A Solt , Yuqiong Liang , Sagar P Bapat , Han Cho , Theodore M Kamenecka , Mathias Leblanc , Annette R Atkins , Ruth T Yu , Michael Downes , Thomas P Burris , Ronald M Evans , Ye Zheng

Neuron-based high-content assay and screen for CNS active mitotherapeutics.

Science advances

Avec: Boglarka H Varkuti , Miklos Kepiro , Ze Liu , Kyle Vick , Yosef Avchalumov , Rodrigo Pacifico , Courtney M MacMullen , Theodore M Kamenecka , Sathyanarayanan V Puthanveettil , Ronald L Davis

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ.

Nature communications

Avec: Zahra Heidari , Ian M Chrisman , Michelle D Nemetchek , Scott J Novick , Anne-Laure Blayo , Trey Patton , Desiree E Mendes , Philippe Diaz , Theodore M Kamenecka , Patrick R Griffin , Travis S Hughes

High throughput screening for compounds to the orphan nuclear receptor NR2F6.

SLAS discovery : advancing life sciences R & D

Avec: Emery Smith , Sean Campbell , Adrianna N Wilson , Justin Shumate , Pierre Baillargeon , Louis Scampavia , Theodore M Kamenecka , Timothy P Spicer , Laura A Solt

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states.

bioRxiv : the preprint server for biology

Avec: Brian MacTavish , Di Zhu , Jinsai Shang , Qianzhen Shao , Zhongyue J Yang , Theodore M Kamenecka , Douglas J Kojetin

SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats.

Frontiers in molecular neuroscience

Avec: Kevin M Braunscheidel , George Voren , Christie D Fowler , Qun Lu , Alexander Kuryatov , Michael D Cameron , Ines Ibañez-Tallon , Jon M Lindstrom , Theodore M Kamenecka , Paul J Kenny

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.

Cell chemical biology

Avec: Beste Mutlu , Kfir Sharabi , Jee Hyung Sohn , Bo Yuan , Pedro Latorre-Muro , Xin Qin , Jin-Seon Yook , Hua Lin , Deyang Yu , João Paulo G Camporez , Shingo Kajimura , Gerald I Shulman , Sheng Hui , Theodore M Kamenecka , Patrick R Griffin , Pere Puigserver

Réseau de co-auteurs

Patrick R Griffin 13 collaborations

Michael D Cameron 9 collaborations

Laura A Solt 8 collaborations

Li Lin 7 collaborations

Yuanjun He 6 collaborations

Gavin Rumbaugh 5 collaborations

Courtney A Miller 5 collaborations

Mi Ra Chang 5 collaborations

Scott J Novick 5 collaborations

Douglas J Kojetin 5 collaborations

Laszlo Radnai 4 collaborations

Sean Campbell 4 collaborations

Erica J Young 4 collaborations

Hua Lin 4 collaborations

Christelle Doebelin 4 collaborations

Rebecca F Stremel 3 collaborations

Alexander Kuryatov 3 collaborations

Timothy S Strutzenberg 3 collaborations

Ruben D Garcia-Ordonez 3 collaborations

Qun Lu 3 collaborations

Di Zhu 3 collaborations

Jinsai Shang 3 collaborations

William H Martin 2 collaborations

Mohammed Amir 2 collaborations

Jingyi Wang 2 collaborations

Jon Lindstrom 2 collaborations

Rebecca L Frkic 2 collaborations

John B Bruning 2 collaborations

Lei Zhang 2 collaborations

Zaira Aversa 2 collaborations

Nathan K LeBrasseur 2 collaborations

Laura J Niedernhofer 2 collaborations

Paul D Robbins 2 collaborations

Chi-Hsiu Liu 2 collaborations

Alexandra K Blomfield 2 collaborations

Jing Chen 2 collaborations

Anne-Laure Blayo 2 collaborations

Madalyn Hafenbreidel 2 collaborations

Paolo Pasetto 2 collaborations

Xiaomin Jin 2 collaborations

Aagam Patel 2 collaborations

Michael Conlon 2 collaborations

Matthew Surman 2 collaborations

Paul J Kenny 2 collaborations

Thomas P Burris 2 collaborations

Claudia Ruiz 2 collaborations

Kfir Sharabi 2 collaborations

Pere Puigserver 2 collaborations

Thomas Vaissiere 1 collaboration

Michael Cameron 1 collaboration

Rajappa Kenchappa 1 collaboration

Natanael Zarco 1 collaboration

Athanassios Dovas 1 collaboration

Christian T Meyer 1 collaboration

Ashley Haddock 1 collaboration

Alice Hall 1 collaboration

Peter Canoll 1 collaboration

Naveen Kh Nagaiah 1 collaboration

Steven S Rosenfeld 1 collaboration

Angelo Blasio 1 collaboration

Holly L Chapman 1 collaboration

Victor Liaw 1 collaboration

Simone M Giovanetti 1 collaboration

Matthew B Pomrenze 1 collaboration

Robert O Messing 1 collaboration

Anthony Ciesla 1 collaboration

Ran Wang 1 collaboration

Sarah A Mosure 1 collaboration

Molly A Bassette 1 collaboration

Amber Eliason 1 collaboration

Mark S Sundrud 1 collaboration

Jack Norleans 1 collaboration

Abba Leffler 1 collaboration

Jing Zhao 1 collaboration

Xiaodong Mu 1 collaboration

Sara J McGowan 1 collaboration

Luise Angelini 1 collaboration

Ryan D O'Kelly 1 collaboration

Matthew J Yousefzadeh 1 collaboration

Ayumi Sakamoto 1 collaboration

Yousin Suh 1 collaboration

Johnny Huard 1 collaboration

Paola Munoz-Tello 1 collaboration

Pasha Khan 1 collaboration

Ian Mitchelle S de Vera 1 collaboration

Davis A Englund 1 collaboration

Alyssa M Jolliffe 1 collaboration

Gabriel J Hanson 1 collaboration

Xu Zhang 1 collaboration

Xinyi Jiang 1 collaboration

Thomas A White 1 collaboration

David G Monroe 1 collaboration

Sundeep Khosla 1 collaboration

Felix Yemanyi 1 collaboration

Kiran Bora 1 collaboration

Neetu Kushwah 1 collaboration

John Paul SanGiovanni 1 collaboration

Ye Sun 1 collaboration

Jordan L Pederick 1 collaboration

Aimee J Horsfall 1 collaboration

Blagojce Jovcevski 1 collaboration

Elise E Crame 1 collaboration

Wioleta Kowalczyk 1 collaboration

Tara L Pukala 1 collaboration

Jie Zheng 1 collaboration

Andrew D Abell 1 collaboration

Joshua S Harbort 1 collaboration

Jeffrey R Harmer 1 collaboration

Carlos Kikuti 1 collaboration

Katalin Toth 1 collaboration

Sherri Briggs 1 collaboration

Leïla Heidsieck 1 collaboration

H Lee Sweeney 1 collaboration

James Sellers 1 collaboration

Teresa Krieger-Burke 1 collaboration

Jay Sisco 1 collaboration

Steven Young 1 collaboration

Paul Pearson 1 collaboration

Gian Luca Araldi 1 collaboration

Steven K Duddy 1 collaboration

Anne Houdusse 1 collaboration

Alexander Duncan 1 collaboration

Mary P Heyer 1 collaboration

Masago Ishikawa 1 collaboration

Stephanie P B Caligiuri 1 collaboration

Xin-An Liu 1 collaboration

Zuxin Chen 1 collaboration

Maria Vittoria Micioni Di Bonaventura 1 collaboration

Karim S Elayouby 1 collaboration

Jessica L Ables 1 collaboration

William M Howe 1 collaboration

Purva Bali 1 collaboration

Clementine Fillinger 1 collaboration

Maya Williams 1 collaboration

Richard M O'Connor 1 collaboration

Zichen Wang 1 collaboration

Avi Ma'ayan 1 collaboration

Heidi C O'Neill 1 collaboration

Ines Ibanez-Tallon 1 collaboration

Aron M Geurts 1 collaboration

Philippe Nuhant 1 collaboration

Naresh Kumar 1 collaboration

Marcel Koenig 1 collaboration

Ruben Garcia-Ordonez 1 collaboration

William R Roush 1 collaboration

Susan Kahn 1 collaboration

Bilel Bdiri 1 collaboration

Mackenzie Geedy 1 collaboration

Joni-Rae Partridge 1 collaboration

James R Sellers 1 collaboration

Bahaa Elgendy 1 collaboration

Kristine Griffett 1 collaboration

Lamees Hegazy 1 collaboration

Paolo Di Fruscia 1 collaboration

Kirby Sample 1 collaboration

Emmalie Schoepke 1 collaboration

Yingmin Zhu 1 collaboration

Dean P Edwards 1 collaboration

Mattia Deluigi 1 collaboration

Alexander Klipp 1 collaboration

Christoph Klenk 1 collaboration

Lisa Merklinger 1 collaboration

Stefanie A Eberle 1 collaboration

Lena Morstein 1 collaboration

Philipp Heine 1 collaboration

Peer R E Mittl 1 collaboration

Patrick Ernst 1 collaboration

Santiago Vacca 1 collaboration

Pascal Egloff 1 collaboration

Annemarie Honegger 1 collaboration

Andreas Plückthun 1 collaboration

Nelson E Bruno 1 collaboration

Jerome C Nwachukwu 1 collaboration

Sathish Srinivasan 1 collaboration

Charles C Nettles 1 collaboration

Tina Izard 1 collaboration

Zhuang Jin 1 collaboration

Jason Nowak 1 collaboration

Siddaraju V Boregowda 1 collaboration

Donald G Phinney 1 collaboration

Olivier Elemento 1 collaboration

Xu Liu 1 collaboration

Eric A Ortlund 1 collaboration

René Houtman 1 collaboration

Diana A Stavreva 1 collaboration

Gordon L Hager 1 collaboration

Kendall W Nettles 1 collaboration

Shuo Huang 1 collaboration

Zhongxiao Wang 1 collaboration

Zhongjie Fu 1 collaboration

William R Britton 1 collaboration

Joshua L Dunaief 1 collaboration

Kevin Greenman 1 collaboration

Robert Drakas 1 collaboration

Mike Lizarzaburu 1 collaboration

Richard Brust 1 collaboration

HaJeung Park 1 collaboration

Christelle Doebellin 1 collaboration

Rémi Patouret 1 collaboration

Christina Chang 1 collaboration

Chin-San Loo 1 collaboration

Xuan Zhao 1 collaboration

Yuqiong Liang 1 collaboration

Sagar P Bapat 1 collaboration

Han Cho 1 collaboration

Mathias Leblanc 1 collaboration

Annette R Atkins 1 collaboration

Ruth T Yu 1 collaboration

Michael Downes 1 collaboration

Ronald M Evans 1 collaboration

Ye Zheng 1 collaboration

Boglarka H Varkuti 1 collaboration

Miklos Kepiro 1 collaboration

Ze Liu 1 collaboration

Kyle Vick 1 collaboration

Yosef Avchalumov 1 collaboration

Rodrigo Pacifico 1 collaboration

Courtney M MacMullen 1 collaboration

Sathyanarayanan V Puthanveettil 1 collaboration

Ronald L Davis 1 collaboration

Zahra Heidari 1 collaboration

Ian M Chrisman 1 collaboration

Michelle D Nemetchek 1 collaboration

Trey Patton 1 collaboration

Desiree E Mendes 1 collaboration

Philippe Diaz 1 collaboration

Travis S Hughes 1 collaboration

Emery Smith 1 collaboration

Adrianna N Wilson 1 collaboration

Justin Shumate 1 collaboration

Pierre Baillargeon 1 collaboration

Louis Scampavia 1 collaboration

Timothy P Spicer 1 collaboration

Brian MacTavish 1 collaboration

Qianzhen Shao 1 collaboration

Zhongyue J Yang 1 collaboration

Kevin M Braunscheidel 1 collaboration

George Voren 1 collaboration

Christie D Fowler 1 collaboration

Ines Ibañez-Tallon 1 collaboration

Jon M Lindstrom 1 collaboration

Beste Mutlu 1 collaboration

Jee Hyung Sohn 1 collaboration

Bo Yuan 1 collaboration

Pedro Latorre-Muro 1 collaboration

Xin Qin 1 collaboration

Jin-Seon Yook 1 collaboration

Deyang Yu 1 collaboration

João Paulo G Camporez 1 collaboration

Shingo Kajimura 1 collaboration

Gerald I Shulman 1 collaboration

Sheng Hui 1 collaboration