Pere Puigserver

Affiliations

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA. Electronic address: pere_puigserver@dfci.harvard.edu.

Publications (28)

A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.

Cell metabolism

Avec: Pedro Latorre-Muro , Katherine E O'Malley , Christopher F Bennett , Elizabeth A Perry , Eduardo Balsa , Clint D J Tavares , Mark Jedrychowski , Steven P Gygi , Pere Puigserver

Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas.

Nature communications

Avec: Jiaxin Liang , Deyang Yu , Chi Luo , Christopher Bennett , Mark Jedrychowski , Steve P Gygi , Hans R Widlund , Pere Puigserver

Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity.

bioRxiv : the preprint server for biology

Avec: Jiaxin Liang , Tevis Vitale , Xixi Zhang , Thomas D Jackson , Deyang Yu , Mark Jedrychowski , Steve P Gygi , Hans R Widlund , Kai W Wucherpfennig , Pere Puigserver

Structure-Activity Relationship and Biological Investigation of SR18292 (

Journal of medicinal chemistry

Avec: Hua Lin , Kfir Sharabi , Li Lin , Claudia Ruiz , Di Zhu , Michael D Cameron , Scott J Novick , Patrick R Griffin , Pere Puigserver , Theodore M Kamenecka

H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP.

The Journal of clinical investigation

Avec: Chi Luo , Eduardo Balsa , Elizabeth A Perry , Jiaxin Liang , Clint D Tavares , Francisca Vazquez , Hans R Widlund , Pere Puigserver

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Long Zhang , Charbel S Hobeika , Damir Khabibullin , Deyang Yu , Harilaos Filippakis , Michel Alchoueiry , Yan Tang , Hilaire C Lam , Peter Tsvetkov , George Georgiou , Candice Lamb , Everett Stone , Pere Puigserver , Carmen Priolo , Elizabeth P Henske

Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.

EMBO reports

Avec: Conor T Ronayne , Thomas D Jackson , Christopher F Bennett , Elizabeth A Perry , Noa Kantorovic , Pere Puigserver

Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.

Cell metabolism

Avec: Jee Hyung Sohn , Beste Mutlu , Pedro Latorre-Muro , Jiaxin Liang , Christopher F Bennett , Kfir Sharabi , Noa Kantorovich , Mark Jedrychowski , Steven P Gygi , Alexander S Banks , Pere Puigserver

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.

Cell chemical biology

Avec: Beste Mutlu , Kfir Sharabi , Jee Hyung Sohn , Bo Yuan , Pedro Latorre-Muro , Xin Qin , Jin-Seon Yook , Hua Lin , Deyang Yu , João Paulo G Camporez , Shingo Kajimura , Gerald I Shulman , Sheng Hui , Theodore M Kamenecka , Patrick R Griffin , Pere Puigserver

Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.

Cancer research

Avec: Chi Luo , Jiaxin Liang , Kfir Sharabi , Maximilian Hatting , Elizabeth A Perry , Clint D J Tavares , Lipika Goyal , Amitabh Srivastava , Marc Bilodeau , Andrew X Zhu , Piotr Sicinski , Pere Puigserver

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.

Nature communications

Avec: Eduardo Balsa , Elizabeth A Perry , Christopher F Bennett , Mark Jedrychowski , Steven P Gygi , John G Doench , Pere Puigserver

GCN5 acetyltransferase in cellular energetic and metabolic processes.

Biochimica et biophysica acta. Gene regulatory mechanisms

Avec: Beste Mutlu , Pere Puigserver

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.

Molecular cell

Avec: Eduardo Balsa , Meghan S Soustek , Ajith Thomas , Sara Cogliati , Carolina García-Poyatos , Elena Martín-García , Mark Jedrychowski , Steve P Gygi , José Antonio Enriquez , Pere Puigserver

Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease.

The FEBS journal

Avec: Christopher F Bennett , Conor T Ronayne , Pere Puigserver

A sweet way to regulate cellular growth: OGT and mTOR join forces.

Molecular cell

Avec: Pedro Latorre-Muro , Pere Puigserver

Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Marta Cruces-Sande , Alba C Arcones , Rocío Vila-Bedmar , Almudena Val-Blasco , Kfir Sharabi , Daniel Díaz-Rodríguez , Pere Puigserver , Federico Mayor , Cristina Murga

Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Clint D J Tavares , Stefan Aigner , Kfir Sharabi , Shashank Sathe , Beste Mutlu , Gene W Yeo , Pere Puigserver

Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives.

Current diabetes reports

Avec: Kfir Sharabi , Clint D J Tavares , Pere Puigserver

Tetracyclines promote survival and fitness in mitochondrial disease models.

Nature metabolism

Avec: Elizabeth A Perry , Christopher F Bennett , Chi Luo , Eduardo Balsa , Mark Jedrychowski , Katherine E O'Malley , Pedro Latorre-Muro , Richard Porter Ladley , Kamar Reda , Peter M Wright , Steven P Gygi , Andrew G Myers , Pere Puigserver

Mechanisms of mitochondrial respiratory adaptation.

Nature reviews. Molecular cell biology

Avec: Christopher F Bennett , Pedro Latorre-Muro , Pere Puigserver

The SLC25A47 locus controls gluconeogenesis and energy expenditure.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jin-Seon Yook , Zachary H Taxin , Bo Yuan , Satoshi Oikawa , Christopher Auger , Beste Mutlu , Pere Puigserver , Sheng Hui , Shingo Kajimura

Structural basis of respiratory complex adaptation to cold temperatures.

Cell

Avec: Young-Cheul Shin , Pedro Latorre-Muro , Amina Djurabekova , Oleksii Zdorevskyi , Christopher F Bennett , Nils Burger , Kangkang Song , Chen Xu , Joao A Paulo , Steven P Gygi , Vivek Sharma , Maofu Liao , Pere Puigserver

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.

Nature chemical biology

Avec: Christopher F Bennett , Katherine E O'Malley , Elizabeth A Perry , Eduardo Balsa , Pedro Latorre-Muro , Christopher L Riley , Chi Luo , Mark Jedrychowski , Steven P Gygi , Pere Puigserver

Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease.

The Journal of clinical investigation

Avec: Beste Mutlu , Pere Puigserver

Atossa: a royal link between OXPHOS metabolism and macrophage migration.

The EMBO journal

Avec: Pedro Latorre-Muro , Pere Puigserver

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival.

bioRxiv : the preprint server for biology

Avec: Conor T Ronayne , Christopher F Bennett , Elizabeth A Perry , Noa Kantorovich , Pere Puigserver

Structural basis of respiratory complexes adaptation to cold temperatures.

bioRxiv : the preprint server for biology

Avec: Young-Cheul Shin , Pedro Latorre-Muro , Amina Djurabekova , Oleksii Zdorevskyi , Christopher F Bennett , Nils Burger , Kangkang Song , Chen Xu , Vivek Sharma , Maofu Liao , Pere Puigserver

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread.

Cell reports

Avec: Deyang Yu , Jiaxin Liang , Hans R Widlund , Pere Puigserver

Réseau de co-auteurs

Christopher F Bennett 11 collaborations

Pedro Latorre-Muro 10 collaborations

Elizabeth A Perry 8 collaborations

Mark Jedrychowski 8 collaborations

Kfir Sharabi 7 collaborations

Eduardo Balsa 6 collaborations

Steven P Gygi 6 collaborations

Jiaxin Liang 6 collaborations

Beste Mutlu 6 collaborations

Deyang Yu 5 collaborations

Chi Luo 5 collaborations

Clint D J Tavares 4 collaborations

Hans R Widlund 4 collaborations

Katherine E O'Malley 3 collaborations

Steve P Gygi 3 collaborations

Conor T Ronayne 3 collaborations

Thomas D Jackson 2 collaborations

Hua Lin 2 collaborations

Patrick R Griffin 2 collaborations

Theodore M Kamenecka 2 collaborations

Jee Hyung Sohn 2 collaborations

Noa Kantorovich 2 collaborations

Bo Yuan 2 collaborations

Jin-Seon Yook 2 collaborations

Shingo Kajimura 2 collaborations

Sheng Hui 2 collaborations

Young-Cheul Shin 2 collaborations

Amina Djurabekova 2 collaborations

Oleksii Zdorevskyi 2 collaborations

Nils Burger 2 collaborations

Kangkang Song 2 collaborations

Chen Xu 2 collaborations

Vivek Sharma 2 collaborations

Maofu Liao 2 collaborations

Christopher Bennett 1 collaboration

Tevis Vitale 1 collaboration

Xixi Zhang 1 collaboration

Kai W Wucherpfennig 1 collaboration

Li Lin 1 collaboration

Claudia Ruiz 1 collaboration

Di Zhu 1 collaboration

Michael D Cameron 1 collaboration

Scott J Novick 1 collaboration

Clint D Tavares 1 collaboration

Francisca Vazquez 1 collaboration

Long Zhang 1 collaboration

Charbel S Hobeika 1 collaboration

Damir Khabibullin 1 collaboration

Harilaos Filippakis 1 collaboration

Michel Alchoueiry 1 collaboration

Yan Tang 1 collaboration

Hilaire C Lam 1 collaboration

Peter Tsvetkov 1 collaboration

George Georgiou 1 collaboration

Candice Lamb 1 collaboration

Everett Stone 1 collaboration

Carmen Priolo 1 collaboration

Elizabeth P Henske 1 collaboration

Noa Kantorovic 1 collaboration

Alexander S Banks 1 collaboration

Xin Qin 1 collaboration

João Paulo G Camporez 1 collaboration

Gerald I Shulman 1 collaboration

Maximilian Hatting 1 collaboration

Lipika Goyal 1 collaboration

Amitabh Srivastava 1 collaboration

Marc Bilodeau 1 collaboration

Andrew X Zhu 1 collaboration

Piotr Sicinski 1 collaboration

John G Doench 1 collaboration

Meghan S Soustek 1 collaboration

Ajith Thomas 1 collaboration

Sara Cogliati 1 collaboration

Carolina García-Poyatos 1 collaboration

Elena Martín-García 1 collaboration

José Antonio Enriquez 1 collaboration

Marta Cruces-Sande 1 collaboration

Alba C Arcones 1 collaboration

Rocío Vila-Bedmar 1 collaboration

Almudena Val-Blasco 1 collaboration

Daniel Díaz-Rodríguez 1 collaboration

Federico Mayor 1 collaboration

Cristina Murga 1 collaboration

Stefan Aigner 1 collaboration

Shashank Sathe 1 collaboration

Gene W Yeo 1 collaboration

Richard Porter Ladley 1 collaboration

Kamar Reda 1 collaboration

Peter M Wright 1 collaboration

Andrew G Myers 1 collaboration

Zachary H Taxin 1 collaboration

Satoshi Oikawa 1 collaboration

Christopher Auger 1 collaboration

Joao A Paulo 1 collaboration

Christopher L Riley 1 collaboration