Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains.

Adult Bipolar Disorder / genetics Brain Chromatin Humans Lysine / genetics Schizophrenia / genetics

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
04 2022
Historique:
received: 02 06 2021
accepted: 09 02 2022
pubmed: 26 3 2022
medline: 9 4 2022
entrez: 25 3 2022
Statut: ppublish

Résumé

Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In this study, we constructed promoter- and enhancer-enriched nucleosomal histone modification landscapes for adult prefrontal cortex from H3-lysine 27 acetylation and H3-lysine 4 trimethylation profiles, generated from 388 controls and 351 individuals diagnosed with schizophrenia (SCZ) or bipolar disorder (BD) (n = 739). We mapped thousands of cis-regulatory domains (CRDs), revealing fine-grained, 10

Identifiants

DOI: 10.1038/s41593-022-01032-6 PMID: 35332326 PMC: PMC8989650
pubmed: 35332326
doi: 10.1038/s41593-022-01032-6
pii: 10.1038/s41593-022-01032-6
pmc: PMC8989650
mid: NIHMS1779367
doi:

Substances chimiques

Chromatin 0
Lysine K3Z4F929H6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

474-483

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH094714
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH103877
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH103365
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH103392
Pays : United States
Organisme : NIMH NIH HHS
ID : DP1 MH129957
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH103346
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH103340
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH103339
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA048279
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH096890
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH105881
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114226
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH106934
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105472
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106056
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIC MH002903
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH102791
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105898
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Kiran Girdhar (K)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu.
ORCID: 0000-0002-5622-042X

Gabriel E Hoffman (GE)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-0957-0224

Jaroslav Bendl (J)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-9989-2720

Samir Rahman (S)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Pengfei Dong (P)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3735-5158

Will Liao (W)

New York Genome Center, New York, NY, USA.
ORCID: 0000-0001-7574-4694

Mads E Hauberg (ME)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Laura Sloofman (L)

Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Leanne Brown (L)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Olivia Devillers (O)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bibi S Kassim (BS)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jennifer R Wiseman (JR)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-5766-636X

Royce Park (R)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Elizabeth Zharovsky (E)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Rivky Jacobov (R)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Elie Flatow (E)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alexey Kozlenkov (A)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Thomas Gilgenast (T)

Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.

Jessica S Johnson (JS)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lizette Couto (L)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Mette A Peters (MA)

Sage Bionetworks, Seattle, WA, USA.

Jennifer E Phillips-Cremins (JE)

Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-4702-0450

Chang-Gyu Hahn (CG)

Department of Psychiatry, Vickie and Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA.

Raquel E Gur (RE)

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Carol A Tamminga (CA)

Department of Psychiatry, The University of Texas Southwestern Medical School, Dallas, TX, USA.
ORCID: 0000-0002-6366-5697

David A Lewis (DA)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-3225-6778

Vahram Haroutunian (V)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY, USA.
ORCID: 0000-0001-5860-2512

Stella Dracheva (S)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY, USA.

Barbara K Lipska (BK)

Human Brain Collection Core, National Institute of Mental Health-Intramural Research Program, Bethesda, MD, USA.

Stefano Marenco (S)

Human Brain Collection Core, National Institute of Mental Health-Intramural Research Program, Bethesda, MD, USA.
ORCID: 0000-0002-2488-2365

Marija Kundakovic (M)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Biological Sciences, Fordham University, Bronx, NY, USA.
ORCID: 0000-0002-6734-4217

John F Fullard (JF)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-9874-2907

Yan Jiang (Y)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
ORCID: 0000-0002-5002-4284

Panos Roussos (P)

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.
Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.
Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.
Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY, USA. panagiotis.roussos@mssm.edu.
Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. panagiotis.roussos@mssm.edu.
ORCID: 0000-0002-4640-6239

Schahram Akbarian (S)

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.
ORCID: 0000-0001-7700-0891

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Chromatin domain alterations linked to 3D...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Chromatin domain alterations linked to 3D...