Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation.
fibrosis
heart failure
hypertrophy
left atrial ischemia
left atrial remodeling
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
pubmed:
26
3
2022
medline:
27
4
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Left atrial (LA) dysfunction is one of the predictive factors of worse outcomes after mitral valve surgery for mitral regurgitation (MR). We aimed to investigate the effect of MR etiology on progression of LA remodeling in swine MR models. MR was induced in 14 Yorkshire pigs using catheter-based procedures. Seven pigs underwent simultaneous occlusions of the left circumflex artery and the diagonal branch, which resulted in ischemic mitral regurgitation (IMR group). The other seven pigs underwent chordal severing to induce leaflet prolapse simulating degenerative mitral regurgitation (DMR group). Changes in LA volume and function were assessed at baseline, 1 mo, and 3 mo using echocardiography and hemodynamic evaluations. Histopathological assessments were conducted to evaluate LA hypertrophy and fibrosis. At 3 mo, quantitative MR severity was comparable and severe in both groups. Despite the similar degree of MR, minimum LA volume index increased significantly more in the IMR group (IMR: 11.9 ± 6.4 to 73.2 ± 6.4 mL/m
Identifiants
pubmed: 35333115
doi: 10.1152/ajpheart.00009.2022
pmc: PMC9037709
doi:
Banques de données
figshare
['10.6084/m9.figshare.19253396.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
H914-H923Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL139963
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007824
Pays : United States
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