Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals.
FGF23
PTH
kidney
phosphate
phosphate transporter
proximal tubule
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
22
03
2022
received:
04
10
2021
accepted:
23
03
2022
pubmed:
26
3
2022
medline:
14
5
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Dietary inorganic phosphate (Pi) modulates renal Pi reabsorption by regulating the expression of the NaPi-IIa and NaPi-IIc Pi transporters. Here, we aimed to clarify the role of several Pi-regulatory mechanisms including parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) and inositol hexakisphosphate kinases (IP6-kinases) in the acute regulation of NaPi-IIa and NaPi-IIc. Wildtype (WT) and PTH-deficient mice (PTH-KO) with/without inhibition of FGF23 signalling were gavaged with Pi/saline and examined at 1, 4 and 12 h. Pi-gavage elevated plasma Pi and decreased plasma Ca (1) Acute downregulation of renal Pi transporters in response to Pi intake occurs also in the absence of PTH and FGF23 signalling, (2) when FGF23 signalling is blocked, a partial contribution of PTH is revealed, (3) IP6 kinases, intracellular Pi-sensors in yeast and bacteria, are not involved, and (4) Acute Pi does not alter PTHrp and dopamine. Thus, signals other than PTH, PTHrp, FGF23 and dopamine contribute to renal adaption.
Substances chimiques
Parathyroid Hormone
0
Parathyroid Hormone-Related Protein
0
Phosphate Transport Proteins
0
Phosphates
0
Sodium-Phosphate Cotransporter Proteins, Type IIa
0
Fibroblast Growth Factors
62031-54-3
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13815Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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