The Macronutrient Composition of Infant Formula Produces Differences in Gut Microbiota Maturation That Associate with Weight Gain Velocity and Weight Status.
diet
gene
infant
infant formula
metabolome
microbiota
randomized controlled trial
rapid weight gain
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
15 Mar 2022
15 Mar 2022
Historique:
received:
28
01
2022
revised:
04
03
2022
accepted:
10
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
This proof-of-principle study analyzed fecal samples from 30 infants who participated in a randomized controlled trial on the effects of the macronutrient composition of infant formula on growth and energy balance. In that study, infants randomized to be fed cow milk formula (CMF) had faster weight-gain velocity during the first 4 months and higher weight-for-length Z scores up to 11.5 months than those randomized to an isocaloric extensive protein hydrolysate formula (EHF). Here we examined associations among infant formula composition, gut microbial composition and maturation, and children's weight status. Fecal samples collected before and monthly up to 4.5 months after randomization were analyzed by shotgun metagenomic sequencing and targeted metabolomics. The EHF group had faster maturation of gut microbiota than the CMF group, and increased alpha diversity driven by Clostridia taxa. Abundance of
Identifiants
pubmed: 35334900
pii: nu14061241
doi: 10.3390/nu14061241
pmc: PMC8951061
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01HD072307
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072307
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK050306
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD094908
Pays : United States
Organisme : Mead Johnson (United States)
ID : Investigator Initiated
Organisme : NIH HHS
ID : R03HD94908
Pays : United States
Organisme : NIH HHS
ID : P30 DK050306
Pays : United States
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