Synthesis and Structural Characterization of Pyridine-2,6-dicarboxamide and Furan-2,5-dicarboxamide Derivatives.
Hirshfeld surface
crystal packing
crystallography
dicarboxamide
heterocyclic compounds
molecular structure
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Mar 2022
10 Mar 2022
Historique:
received:
07
02
2022
revised:
22
02
2022
accepted:
08
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Derivatives based on pyridine-2-6- and furan-2,5-dicarboxamide scaffolds reveal numerous chemical properties and biological activities. This fact makes them an exciting research topic in supramolecular and coordination chemistry and in discovering new pharmacologically-active compounds. This work aimed to obtain a series of symmetrical pyridine-2-6- and furan-2,5-dicarboxamides through a condensation reaction of the appropriate acyl chlorides and aromatic amides. Successful syntheses were confirmed with NMR spectroscopy. We solved their crystal structures for seven compounds; two pyridine and five furan derivatives. Based on our crystallographic studies, we were able to indicate supramolecular features of the crystals under investigation. Additionally, Hirshfeld surface analysis allowed us to calculate a distribution of intermolecular contacts in the dicarboxamide crystals.
Identifiants
pubmed: 35335183
pii: molecules27061819
doi: 10.3390/molecules27061819
pmc: PMC8948770
pii:
doi:
Substances chimiques
Amides
0
Furans
0
Pyridines
0
pyridine-2,6-dicarboxamide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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