Structure-Based Molecular Networking for the Discovery of Anti-HBV Compounds from
Saussurea lappa
anti-HBV activity
sesquiterpenes
structure-guided isolation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Mar 2022
21 Mar 2022
Historique:
received:
01
03
2022
revised:
11
03
2022
accepted:
16
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
It is a crucial to find target compounds in natural product research. This study presents a concept of structure-guided isolation to find candidate active molecules from herbs. We establish a process of anti-viral sesquiterpene networking. An analysis of the networking suggested that new anti-HBV sesquiterpene may be attributable to eudesmane-, guaiane-, cadinane-, germacane- and bisabolane-type sesquiterpenes. In order to evaluate the efficiency of the structure-based molecular networking, ethanol extract of
Identifiants
pubmed: 35335386
pii: molecules27062023
doi: 10.3390/molecules27062023
pmc: PMC8955460
pii:
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
Plant Extracts
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81973210
Organisme : National Natural Science Foundation of China
ID : 31960093
Organisme : Ronald J Quinn AM Academician Workstation
ID : 2019IC003
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