Mutations and Evolution of the SARS-CoV-2 Spike Protein.
COVID-19
SARS-CoV-2
evolution
immune escape
infectivity
mutation
spike
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
19 03 2022
19 03 2022
Historique:
received:
30
01
2022
revised:
12
03
2022
accepted:
16
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
1
4
2022
Statut:
epublish
Résumé
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis of new SARS-CoV-2 variants with greatly enhanced overall fitness. Given the trend of variants with increased fitness arising from spike protein alterations, it is critical that the scientific community understand the mechanisms by which these mutations alter viral functions. As of March 2022, five SARS-CoV-2 strains were labeled "variants of concern" by the World Health Organization: the Alpha, Beta, Gamma, Delta, and Omicron variants. This review summarizes the potential mechanisms by which the common mutations on the spike protein that occur within these strains enhance the overall fitness of their respective variants. In addressing these mutations within the context of the SARS-CoV-2 spike protein structure, spike/receptor binding interface, spike/antibody binding, and virus neutralization, we summarize the general paradigms that can be used to estimate the effects of future mutations along SARS-CoV-2 evolution.
Identifiants
pubmed: 35337047
pii: v14030640
doi: 10.3390/v14030640
pmc: PMC8949778
pii:
doi:
Substances chimiques
Membrane Glycoproteins
0
Spike Glycoprotein, Coronavirus
0
Viral Envelope Proteins
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIBIB NIH HHS
ID : R21 EB031310
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA029348
Pays : United States
Organisme : NIH HHS
ID : U01 AA029348, R21 EB031310
Pays : United States
Commentaires et corrections
Type : ErratumIn
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